Package: nem
Title: Nested Effects Models to reconstruct phenotypic hierarchies
Version: 2.34.0
Author: Holger Froehlich, Florian Markowetz, Achim Tresch, Theresa Niederberger, Christian Bender, Matthias Maneck, Claudio Lottaz, Tim Beissbarth
Description: The package 'nem' allows to reconstruct features of pathways from the nested structure of perturbation effects. It takes as input (1.) a set of pathway components, which were perturbed, and (2.) high-dimensional phenotypic readout of these perturbations (e.g. gene expression, protein expression). The output is a directed graph representing the phenotypic hierarchy.
Reference: Froehlich H, Beissbarth T, Tresch A, Kostka D, Jacob J,
        Spang R, Markowetz F: Analyzing gene perturbation screens with
        nested effects models in R and bioconductor, Bioinformatics,
        2008, 24:2549-50.
Maintainer: Holger Froehlich <frohlich@bit.uni-bonn.de>
Depends: R (>= 2.0), e1071 (>= 1.5), graph (>= 1.24), plotrix, limma,
        cluster (>= 1.11), statmod, Hmisc, Rgraphviz
Enhances: doMC, Rglpk
Imports: boot, e1071, graph, graphics, grDevices, methods, RBGL (>=
        1.8.1), RColorBrewer, stats, utils, Rgraphviz
Suggests: Biobase (>= 1.10)
LazyLoad: Yes
biocViews: Microarray, Bioinformatics, GraphsAndNetworks, Pathways
URL: http://www.bioconductor.org
License: GPL (>= 2)
Packaged: 2012-10-02 06:37:12 UTC; biocbuild
Built: R 2.15.1; i386-pc-mingw32; 2012-10-02 13:08:40 UTC; windows
Archs: i386, x64
