get_tf_ES {MethReg} | R Documentation

## Calculate enrichment scores for each TF across all samples using dorothea and viper.

### Description

Calculate enrichment scores for each TF across all samples using dorothea and viper.

### Usage

    get_tf_ES(exp, min.confidence = "B", regulons)

### Arguments

`exp` | Gene expression matrix with gene expression counts, row as ENSG gene IDS and column as samples
`min.confidence` | Minimun confidence score ("A", "B","C","D", "E") classifying regulons based on their quality from Human DoRothEA database. The default minimun confidence score is "B"
`regulons` | DoRothEA regulons in table format. Same as run_viper. If not specified Bioconductor (human) dorothea regulons besed on GTEx will be. used dorothea_hs.

### Value

A matrix of normalized enrichment scores for each TF across all samples

### Examples

    gene.exp.chr21.log2 <- get(data("gene.exp.chr21.log2"))
    tf_es <- get_tf_ES(gene.exp.chr21.log2)

[Package MethReg version 1.4.0 Index]