computeHpIC {PCAN} | R Documentation

## Compute Information Content (IC) for each HP based on genes by HP

### Description

Compute Information Content (IC) for each HP based on genes by HP

### Usage

    computeHpIC(content, hp.descendants)

### Arguments

`content` | a list providing the content associated to each HP
`hp.descendants` | a list providing for each HP all its descendant HP terms

### Details

This function assumes that all the HP terms taken into account belong to the same family of terms(i.e they are all descendants of the same term).

### Value

a vector of IC named with HP terms

### Examples

    ###########################################
    ## Compute information content of each HP according to associated genes
    data(geneByHp, hp_descendants, package="PCAN")
    geneByHp <- unstack(geneByHp, entrez~hp)
    ic <- computeHpIC(geneByHp, hp_descendants)
    hist(
        ic,
        breaks=100, col="grey",
        main="Distribution of Information Content",
        xlab="IC base on genes associated to HP"
    )

[Package PCAN version 1.22.0 Index]