LOCUS       GU_179289              235233 bp    DNA     linear   VRL 09-MAY-2013
DEFINITION  Human herpesvirus 5 strain VR1814, complete genome.
ACCESSION   GU179289
VERSION     GU179289.1  GI:270355759
KEYWORDS    .
SOURCE      Human herpesvirus 5 (HHV-5)
  ORGANISM  Human herpesvirus 5
            Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
            Betaherpesvirinae; Cytomegalovirus.
REFERENCE   1  (bases 1 to 235233)
  AUTHORS   Dargan,D.J., Douglas,E., Cunningham,C., Jamieson,F., Stanton,R.J.,
            Baluchova,K., McSharry,B.P., Tomasec,P., Emery,V.C., Percivalle,E.,
            Sarasini,A., Gerna,G., Wilkinson,G.W. and Davison,A.J.
  TITLE     Sequential mutations associated with adaptation of human
            cytomegalovirus to growth in cell culture
  JOURNAL   J. Gen. Virol. 91 (PT 6), 1535-1546 (2010)
   PUBMED   20479471
REFERENCE   2  (bases 1 to 235233)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2009) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
COMMENT     The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Location/Qualifiers
     source          1..11820
                     /organism="Human herpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="VR1814"
                     /isolation_source="cervical secretions of a pregnant woman
                     with a primary HCMV infection"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="Italy"
                     /collection_date="1996"
                     /note="unpassaged strain in the original clinical sample;
                     acronym: HCMV; acronym: HHV-5"
     variation       534..588
                     /note="complex, uncharacterized variations"
     variation       773
                     /note="minor in fibroblast cell passage 214"
                     /replace="c"
     variation       10999..11505
                     /note="major in fibroblast cell passage 214; major in
                     endothelial cell passage 199"
                     /replace=""
     variation       11775^11776
                     /gene="RL13"
                     /note="major in fibroblast cell passage 214; major in
                     endothelial cell passage 199"
                     /replace="a"
ORIGIN      
        1 ccattccggg ccgcgtgctg ggtccccgag gggcgggggg gtgttttttt cgggggggtg
       61 aaaattggag ttgcgtgtgt ggacggcgaa tagttgcgtg tggtgcggag gacggcgacg
      121 gcgaataaaa gcgacgtgcg cggcgcacgt cgcaaagaag acgcgtgtct gtgtctgtct
      181 gattccccgg ggaaaagagg gagttcccag gggacggcag cgcgggtccc tggggacaca
      241 cgaaaaacaa cggccagaga caagacgcgg aaaagaggaa gtccctaggg gaccgcgagg
      301 gcaacgacag acgaagtacg gcacaacccg cgtcgaggac acacgcagag gcggtcgccc
      361 aggggagggg ggggggtcgc ggaccccgtg gcacactgct tccatccagc cgcgcacacc
      421 gcacccctga cacaccccgc cagcacaccc ccgacacacc cgccacacgc ccgcgacaca
      481 ccctgacaca cccggcacac gccctgacac acccggcaca cccgacaccc accccacgca
      541 cgcacccagc cgcgccccag acacaccccg acagccgcca gcccggcaca ccccgaccgc
      601 cgccagtgcg ggacagggct gagcgacttc ttggcgccgt aagcgcgccg ccgcttctgc
      661 ggcgtgttcc ccacggcgct tcctgcgcgc ttccggtgcg tcaaggagtt ctgcggtgtt
      721 tgttcacggt ccggcgctgg ggacggggtg tttcgggcgc tcggagggct ttggcggcgg
      781 gtgtttgcac ggagtttcta gtaagctttt gcgcggcgct tcgcttttcg gggcggggac
      841 ggcggtgttt tcgggcgtac tggggttgac ggcgctggta acgggagttc cgctggggac
      901 gggtacgggg gttgcgccgg gaacgggggg tgtgcgtggg tgtgcggggc cgggcacggg
      961 ggccttttgc ggcggggacg gtggtgggga cggcgcgttg cgggaccggg gacggaggtg
     1021 gcgccggaga cacggggtga cgtcggagac aggggccttt tgcggcaggg acggggcgtt
     1081 tgcggcgggg acgggggcct ttcgcggcgg acacggggac gggggtggcg ccggggacgg
     1141 gggcctttcg cggcggggaa cacagacggc acgcacacgc agctcgccta tttaacctcc
     1201 acccactacc acacacacat gccgcacaat catgccaacc acagacacaa acagcaccca
     1261 caccacgccg cttcacccag aggaccaaca caccttaccc ttacaccaca gcaacacaca
     1321 accgcatgtc caaacctcgg acaaacacgc cgacgaagaa caccgcacgc acatggagct
     1381 tgacgccgcg gactacgctg cttgcgcaca ggcccgccaa cacctctacg gtcaaacaca
     1441 accccaacta cacacatacc ccaacgccaa cccacaggaa agcgctcatt tttgcacaga
     1501 gaatcaacat caactcacgc atctacttca caacattggc gagggcgcag cgctcggcta
     1561 ccccgtccca cgcgcggaaa tccgccgcgg cggtggcgac tgggccgaca gcgcaagcga
     1621 cttcgacgcc gactgctggt gcatgtgggg acgcttcgga accatgggcc gccaacctgt
     1681 cgtaacctta ctgttggcgc gccaacgcga cggcctcgct gactggaacg tcgtacgctg
     1741 ccgcggaaca ggctttcgcg cacacgattc cgaggacggc gtctctgtct ggcgtcagca
     1801 cctggttttt ttactcggag gccacggccg ccgtgtacaa ttagaacgac catccgcggg
     1861 agaagcccaa gctcgaggcc tattgccacg catccggatc acccccatct ccacatctcc
     1921 acgcccaaaa ccaccccagc ccaccacatc caccgcatcg cacccacatg ctacggctcg
     1981 gccagatcac acgctctttc ctgtcccttc tacaccctca gccacggttc acaatccccg
     2041 aaactacgcc gtccaacttc acgccgaaac gacccgcaca tggcgctggg cacgacgcgg
     2101 tgaacgtggc gcgtggatgc cggccgagac atttacgtgt cccaaggata aacgtccctg
     2161 gtagacgtgg tagggggatc taccagccca gggatcgcgt ctttcgccgc cacgctgctt
     2221 caccgatatc caataaaccc atcccctcgc cacgacgtct ccgcgtatct ttgtagcctc
     2281 aggaatccgt ccccacgtcc acccatcccg agcactccac acgctataac agaccacgga
     2341 cacggcaaaa aatgcatgca aacttctcat ttattgtgtc tactactctg tgttgctaca
     2401 gggagtgaag ggggtgaagg caaagaaaaa aaaaaggaac aaaataatag attagcagaa
     2461 ggaataatcc gtgcgaccga gcttgtgctt cttttcttat aaggaggcaa atatactagg
     2521 gaaaacataa gaataggaag aaaccgaggt ttgggagaaa agctgagata aaatagcgca
     2581 ttttccatac agaggttgtt gtttttgtgg atcctaagag gtttcaagtg cgaatctcaa
     2641 agttctcacg agaatattgt cttcaagaat cgacaactgt ggtccaagat ttttttttgg
     2701 tctttttagg ttctgcgagg gacatcacga tggatcgttg cgatgaagtc acgcgtacgc
     2761 ctctggtgtg gcgcggtgtc gtgacaggag agtgtgtttt cagtgcagag ctgtcttgat
     2821 tcctatatcc gagtatctgt tttctcgtaa ggacggtaat cttctttggt gtaagtacat
     2881 ctaaaagctg caaactatat tttaagggct gtctctaggt gtactttgat gctggagttt
     2941 ttcgctgtgt tgatgtgaat aaatctacta ctactattat atgcagaaag agtgattatg
     3001 ccgagacaag attgcattgg ctgaactgtt tcaaaaacgc ctacactcta cttatccgta
     3061 aacctaaggt aatactatgt gtaagttgtt tttttttctt tttgtagtaa aatggtgata
     3121 cgtgcaatta aaactgtatt ccatgtttcc atcctttcat ttcaacttta aaggcggctt
     3181 tgagagcgaa gaagtgcgag gataaaaatg gatgactcct tcgtgtccag ggagtcgact
     3241 actgcaacgc tgattgatta aaagatggtc tccgatgatg atgttgttat tgatcgaatc
     3301 atggtgcaga acggcgacgg agaggagcgt gtccgccgcc gggaaggtgg tctctttctc
     3361 ttttcttttt tcaagaaatc ttccatgtgt ttatcgtagt gatcgaaatc gactgatctc
     3421 gggttctttt tgttggtttc ttttcggtta atcatgtatt gttttctttt tttacagaaa
     3481 gatacttttt tcatgagcaa ttcctcgccc ggcgccggca tgccgaggtg gggccactgc
     3541 gatcagcggc atgccgacgc cgacccgggg atcttggatt caccgttttc tctcttctct
     3601 ctctacatac agaccgggtg gcaggagcgg taaggaatca tcgtcgtctt tcattcttcg
     3661 atgattatgg taatactaaa tcttatctag gagcatatac atctaagatt ggagtactag
     3721 tagtcgtttg tggtttctat ttttttttat atttatctat gacagttttt ctgtttttcg
     3781 ttttgataat aatataataa aaactcatgg acgtgaaatc tggcttggtt gtggtgattt
     3841 cattctcatt attgttgttt tctttccgtc ttgcggatga agatgttgcg atgcggttgt
     3901 tgttggtgtt gctatacacc gagagagatg atctttttgt tcttctggtt catttcctat
     3961 gattgtttgg ctgctgaccg acgcgtcagg atgtgcaggg catgcgggga atcaggaccg
     4021 gacacgggat aatttcatct acctatacgg agatcgcggt cctcgccacg aggatcgcga
     4081 caggcgcgtc gagggggcag gaacaccctt gcggattgac attcttggtg gtgtttcgtt
     4141 gttgtcggta gttgttgttg acgatgagga taaataaaaa tgaccttgtt tttgttctgt
     4201 tttctcttgt tgggaatcgt cgactttgaa ttcttcgagt tatcggaaag ctgaggtacc
     4261 caaatgtctg tagctttttt ctttttaccc tcttgtttat catctgcgat tcgtggtagg
     4321 taggagaggg aaatgataat ccgagattaa ggaaaggaga agataaaaaa taaaaaaaaa
     4381 aaaaaacaga agccgaccgg ccgccgaccc gttccccagg accagcctac ggggaacgga
     4441 taacgcggtg gcgacggcag cggtggtggc gctgggggtg gcggtagtgg tgctgctgat
     4501 ggtagtcggg acggaggaga gacgatgcat acatacacgc gtgcatgctg catgggtgga
     4561 tggtacggcc gggagacgcg gaagagaaac tcacataaaa aggtgacaaa aagagcggtt
     4621 gaaaaaagaa aacgagattc gaccagacag aagagaagga ccggggcttg gcgacccttc
     4681 cacgactgct gttgtcatct cggctcctcc gtcttctccc ggccacgggc ggctaagtca
     4741 ccgccgttct ccccatccgt ccgagcgccg accgaccagc cggccgattc gcccgccggg
     4801 gcttctggag aacgccgggg cagcagcgat ctggggaagc cgctaaaccc ctgcgttttt
     4861 atatggtagc tctgccgagc gcgggctgac gcgttgagta agcggaaaga cgtgtgtgac
     4921 gaaaaggggt cccatggtat ttcacgtgac gatgaggaga tgcggtttgg agcacatacg
     4981 gtttagaaaa agggagttgt cgtgacaagg gctgagggac ctctgtctcc atgtgtgtat
     5041 aaaaagcaag gcacgttcat aatgtaaaaa agaacacgtt gtaaacaagc tattgctgta
     5101 tcattcggct gactatgctt cattcggact gattttcttt tcctaacggc gtaacttaaa
     5161 gtgattaacg tatgatattt gttccccaga gttatactat agtcatcatc ctaaaattca
     5221 gatataaatg aacacacgtc gtatgggatt attaagaaac cgaaactctc cacagttcac
     5281 catcttcttc gtcattcaac cgatgaccca ctccgtacaa cgaatcagtc tgctgcgtca
     5341 tattgcaaag cacaagcgac gtatgcgaac aacttgaaac acaggctgtt gtattgatga
     5401 ccgttgtacc attattagtc acatcgtata gagactctcc accgtcatcc catgtttccc
     5461 acccgatgga aaaccgtctt ctatcatcaa ctgtggtaag atttcgaccc tgcgaggtat
     5521 tcagtttcct catatccata acctggattt tatcattaaa ccccaatatt aaatactttt
     5581 ttagtacccc ccacccacca aaaaatgtga ctggaccggt tcctagcagc tctgggagcc
     5641 atgttcaggt tgaaccacag ctacagcgaa accgagtcca gtgaccggta accacgtcca
     5701 gcccctgcgt atgtaccagt ccaagcacgt ccggtcattg ttctacacag gaaatctaac
     5761 taggtcaacg caattttatt ccaccgttac gcagaatact aacaaaaaaa cacacaaatt
     5821 taacgaatta cacgtagttt attacatgaa aactgtaaga acaccaattc actaagcgat
     5881 acaacattta gctgacttcc aagtgccaca catcaccact gtattcatcc atgttttcac
     5941 cgaaccaacg agacagatcg aagaagccag aatctcccga ctttaaatta cataaatcca
     6001 acgtattatg accacagctc gacacacaaa tagttgcgtt actattcaca gtagcattac
     6061 ctatacccgt aacgttgcac aaccactgat caccattgtt accaaaaacg gttttccact
     6121 tagttgtcaa cggatctttc ctatgcgtaa tggtaaaatt actaccagtc gtcgctttta
     6181 gctcattacg agtattatcc gcatccacat atatcaacgt catagctagg cacgctataa
     6241 gtaccccccc cccacaatgg aatgttgcca aaccggttct ttcccgttat agccatagcg
     6301 ttcccaggca aaagcaaacg ccaaacctaa tgcagtgaaa agcgcttgca gccagaacca
     6361 gcttatgtac cagccacaat cacatccggt tattgtttcc acaggaaatc ctaccaggca
     6421 aagccccgct tgttttgttc ctgactatct tgtttagcaa ttcgtaaact gtcagcctag
     6481 cgacgtccgt ttagatcaaa agtcacgtat atagcgacgc tgtttccatc cgtttccccg
     6541 tcccgccgtt tccgaacaac ccacccgggt tcagacaacc gaccaccaac agaaatatac
     6601 acacagacca ctgggagttc agttaaagat ttcatcaggt ttattttggc tgctgctagt
     6661 cttttgcttc ttagaaaaaa aatacccata tagagaaata atgatagttt gacaacacat
     6721 atggcaggga tttcttcttc atcaataaga tatgcaattc ccccagggag agactttcaa
     6781 caattgaatt tacaaaaaca aaattacatc aggagaaaga gaggatacat taataaatat
     6841 attatatctg gtgtatatac tgaatgctgc tggttcataa ggtaacgatg ctactttttt
     6901 taattccaag atggtttttc tttgttagtc ttttgttgac ttgctggttc ctaaaagttc
     6961 gcaaaaacga ttgtgtgaag attttatgac gttggttgac tagttcatga gattctgctg
     7021 tacgtgtgat ggttattcgc tggttcgttc taagatgagt atcgtactgt gtctgcgatg
     7081 gtcgtctctt actggcattc tctcggctgc ctcttgcttt catgattgaa aaggaaaaaa
     7141 ggactccgag ggcgcggtca tcttttactt ttcggttttc tcattggcgg gtcagaggta
     7201 gtcagatcat gagactgtcg tggtcgatga aactgtgtct gctcaagtga cgtccatttc
     7261 ttgtacggag aaaaaagtca tcgggataaa taaggctata caaggcgttg tcaagcgtgc
     7321 ggctctaaac aaattaagcg atacaaaatt acagtaatac gaataataaa ttacccccct
     7381 ccccctgtgg tcccccgaga cgagagccac ccatcgtgta ctctcgcacc acccacgacc
     7441 acagagggag gcgggacgaa gagacgacgc agagcgccat ctcctcctga aggccggcga
     7501 cgttaactgc tacagctgcg gcggcgacga cgacagctgc gatttgtcgg ccgacatgcc
     7561 gatggtatgg gcggcggcgg cagtggccgc ggcagcgggg aggagaggag agagaagagg
     7621 agcggggcgt ccgaaggcga ggatggcatg gtctcgccgg agcgcccggc ttttatggga
     7681 cactcgcgtc cggttgggca ttgcccacag gaagatgagt cacaacttcc aaaccatctt
     7741 gagacccgag taacggttta caggtcgcac gccagtctca gctaaaaaca gcggacagtc
     7801 ccacgctgtt tctgttgtgg ctctctccag tttcctcatc gccatcccgg tctccgtcgt
     7861 catcggaaga ataccatccg ctctcatgcg gcagtcgatc gacctcgacg aacgagacgc
     7921 ggcgacgcct ctctacggcc gactggttgt ggtggtgaaa gaagagcacc agcaatccca
     7981 ggaggagcaa caagccctca catgtccagg aggtcgggga gagggcctgt cggagatggc
     8041 cgtgaggcat cacgtacggc agctgaggag aaacggagaa gaaaggaaaa ttaccgtcag
     8101 gggccggggt tcttattaga aaaacagcac gtaggtcagg atccagatgc taatggcgat
     8161 catgatgacg atgatcatgc aggccaagac gcggcgcacc aatgccgaat ccaagagccg
     8221 ccgtgccgcc ggttggtggc tggcggcatc tagagacatg gtttgggggg gaccggcggc
     8281 gcgaaaagac agggagatgg acagtgacac ggtgttttgt tatgattagg acatggggac
     8341 cggaagccga gacagagtac tacagagtgt tgaagggtaa cgtgagggag atcatgtcat
     8401 gggcgggctg aagaccgtgc ggggaggatc gacgtgtgcg gtgcttgtgg aacacggtgt
     8461 tttaatatgt atccgcgtgt aatgcacgcg gtgtgctttt tagcactcgg tttgataagc
     8521 tacgtggccg tttgcgccga aaatacggtt accaccaatt gtctcgtgaa aacagaaaat
     8581 acccacctaa catgtaagtg caatccgaat agcacatcta ccaatggcag caagtgccac
     8641 gcgatgtgca aatgccgggt cacagaaccc attacaatgc taggcgcata ctcggcctgg
     8701 ggcgcgggct cgttcgtggc cacgctgata gtcctgctgg tggtcttctt cgtaatttac
     8761 gcgcgcgagg aggagaaaaa caacacgggc accgaggtag atcaatgtct ggcctatcgg
     8821 agcctgacac gcaaaaagct ggaacaacac gcggctaaaa agcagaacat ctacgaacgg
     8881 attccatacc gaccctccag acagaaagat aactccccgt tgatcgaacc gacgggcaca
     8941 gacgacgaag aggacgagga cgacgacgtc tgacaaggaa ggcgagaacg tgttttgcac
     9001 catgcagacc tacagcaccc ccctcacgct tgtcatagtc acgtcgctgt ttttgttcac
     9061 aactcaggga agttcatcga acgccgtcga accaaccaaa aaacccctaa agctcgccaa
     9121 ttaccgcgcc acctgcgagg accgtacacg tactctggtt accaggctta acactagcca
     9181 tcacagcgta gtctggcaac gttatgatat ctacagcaga tacatgcgtc gtatgccgcc
     9241 actttgcatc attacagacg cctataaaga aaccacgcat cagggtggcg caactttcac
     9301 gtgcacgcgc caaaatctca cgctgtacaa tcttacggtt aaagatacgg gagtctacct
     9361 cctgcaggat cagtataccg gtgatgtcga ggctttttac ctcatcatcc acccacgtag
     9421 cttctgccga gctttggaaa cgcgtcgatg cttttatccg ggaccaggga gagttgtggt
     9481 tacggattcc caagaggcag accgagcaat tatctcggat ttaaaacgcc agtggtccgg
     9541 cctctcactc cattgcgcct gggtttcggg actgatgatc tttgttggcg cactggtcat
     9601 ctgctttctg cggtcgcaac gaatcgggga acaggacgct gaacggttgc ggacggacct
     9661 agatacggaa cctctgttgt tgacggtgga cggggatttg gagtaaaaga tgcgcacaca
     9721 acatcgacgg tggaacaagt catcatatac gcaaataata tgcatgttta ttattttttg
     9781 gattctgcag aaaagcaagt gtaacaacac cactatcgcc aatacttcca cgtcgattac
     9841 acccacaagc ttaatatcta ctacacaact gacatctacg ttacaaacca ccgaaatgtc
     9901 taccactatg ttcacatcct ccaatggcaa cgtcaacaca tccacaggat tcactgcaag
     9961 ctctgtaaaa ggcacagacg tgacctcaac tatttccacc atatctaccc aaacatctac
    10021 aactaacgta actgtaataa caacttcacc aaacggcgac acgaattcat cgacacagca
    10081 tgtaaccgat agtactgtga ctttgcaaac tatatcatta tcaaccaaca ctactactat
    10141 gataaatgca aatgaaaacg tcactacacc gcttccaact tgctcatcgc ctaacagtac
    10201 aaataatacg atatcaaaag aatctgaaac attattggag gcggcacaag gagacaatat
    10261 tactataaca cacaacctaa ccatcacatc gtgctacaaa acagcctggc ttagacattt
    10321 taatatatcc acacacggaa aatacaccca tcccaacata agaaatggaa aatatcataa
    10381 ccattcattg aaaatcctcc attcgcgtat actatgtgag tggcacacaa attatctaaa
    10441 acatcactat gatttatgtt ttacatgcga tcgtaattta tctttatctc tgtacggtct
    10501 taattttact cattctggta aatatagctt tcgatgttat aaaactgggc atccctccga
    10561 acaaaatcaa aactttaatc tgcaaataca tcctagaaac aacacaaacg ggacacacgt
    10621 gaatccctgg gtatgtgaag aaccaaagca cgaatgggac acttctcata aaccgaccaa
    10681 ttatgaagac aatacagcca catcatctat agatcattta taccgctata acaatcattc
    10741 taacacatca cacggcagac gcactacgtg gacgttagca ttaatttgtg tagcctgcat
    10801 tctcctattt ttcgtccgac gagctctaaa taaaaaatat catccattaa gtgacgatat
    10861 aagtgaatca gaattcatag ttcgatacaa tcctgagcac gaggactaag caacgtttcc
    10921 ggataaatgt cttatgagac catatcagaa aataaacggg caagaaagat caacaacgtc
    10981 cgaagaaaca tcaatgcccc gttaaccgaa atttaataac gttatggact ggagatttac
    11041 ggttaagtgg acgttactga tgattacgat atctgaaggt tgcaatgaca cgtgctcctg
    11101 tccgtgcaat tgccttacct ccaccgcctc cactatcaca aattcttcta actctgtcac
    11161 cgatgctaac agcacttcag ctatcgcaaa tggaaccacg cacaaaccct ctaccgcttc
    11221 ttcagtcgca tcagcaacca cttcaacgct ttcaaaatca tcgtcaagcg ctacgccaac
    11281 attaacgttt tctaccattc atagtactac tccctggttg aataccagca acataacttg
    11341 caatggcagt ttgtacaccg tttataaaca ctctaattta aattacgaag taattaatgt
    11401 aacaggatat gtcggtggat acgtcacttt gaaaaactgc agtagaacgg atgtatggca
    11461 cgatatagaa tggataaaat atggacctcg cgcacaccaa ctgtgcagca ttggacatta
    11521 ttattcaact tccccactga acggcatgtg tttagactgc aataagacct ctctcactat
    11581 atacaacgta actaccgaac acgctggaaa atacgttttg caacgttaca gtgacggtaa
    11641 aaaggaaaac tactatttaa ccgtgttatc aggaactgca acatcgtctc ctatacctga
    11701 taaatgtaaa acaaaagagg aatcagacca gcataatagc agaacgtggg acaatgtaat
    11761 aaaaactgta aaaaacacta acattcccct gggaattcat gctgtatggg cgggtatagt
//
