compute.proto.cor.meta {genefu} | R Documentation

## Function to compute correlations to prototypes in a meta-analytical framework

### Description

This function computes meta-estimate of correlation coefficients between a set of genes and a set of prototypes from a list of gene expression datasets.

### Usage

    compute.proto.cor.meta(datas, proto, method = c("pearson", "spearman"))

### Arguments

`datas` | List of datasets. Each dataset is a matrix of gene expressions with samples in rows and probes in columns, dimnames being properly defined. All the datasets must have the same probes.
`proto` | Names of prototypes (e.g. their EntrezGene ID).
`method` | Estimator for correlation coefficient, can be either pearson or spearman

### Value

A list with items: -cor Matrix of meta-estimate of correlation coefficients with probes in rows and prototypes in columns. -cor.n Number of samples used to compute meta-estimate of correlation coefficients.

### See Also

map.datasets

### Examples

    # load VDX dataset
    data(vdxs)
    # load NKI dataset
    data(nkis)
    # reduce datasets
    ginter <- intersect(annot.vdxs[ ,"EntrezGene.ID"], annot.nkis[ ,"EntrezGene.ID"])
    ginter <- ginter[!is.na(ginter)][1:30]
    myx <- unique(c(match(ginter, annot.vdxs[ ,"EntrezGene.ID"]),
      sample(x=1:nrow(annot.vdxs), size=20)))
    data2.vdxs <- data.vdxs[ ,myx]
    annot2.vdxs <- annot.vdxs[myx, ]
    myx <- unique(c(match(ginter, annot.nkis[ ,"EntrezGene.ID"]),
      sample(x=1:nrow(annot.nkis), size=20)))
    data2.nkis <- data.nkis[ ,myx]
    annot2.nkis <- annot.nkis[myx, ]
    # mapping of datasets
    datas <- list("VDX"=data2.vdxs,"NKI"=data2.nkis)
    annots <- list("VDX"=annot2.vdxs, "NKI"=annot2.nkis)
    datas.mapped <- map.datasets(datas=datas, annots=annots, do.mapping=TRUE)
    # define some prototypes
    protos <- paste("geneid", ginter[1:3], sep=".")
    # compute meta-estimate of correlation coefficients to the three prototype genes
    probecor <- compute.proto.cor.meta(datas=datas.mapped$datas, proto=protos,
      method="pearson")
    str(probecor)

[Package genefu version 2.26.0 Index]