scmod2.robust {genefu} | R Documentation

## Subtype Clustering Model using ESR1, ERBB2 and AURKA modules for identification of breast cancer molecular subtypes (Desmedt et al 2008)

### Description

List of parameters defining the Subtype Clustering Model as published in Desmedt et al 2008.

### Usage

    data(scmod1.robust)

### Format

List of parameters for SCMOD2:

- parameters: List of parameters for the mixture of three Gaussians (ER-/HER2-, HER2+ and ER+/HER2-) that define the Subtype Clustering Model. The structure is the same than for an `mclust::Mclust` object.

- cutoff.AURKA: Cutoff for AURKA module score in order to identify ER+/HER2- High Proliferation (aka Luminal B) tumors and ER+/HER2- Low Proliferation (aka Luminal A) tumors.

- mod: ESR1, ERBB2 and AURKA modules.

### Source

http://breast-cancer-research.com/content/10/4/R65k

### References

Wirapati P, Sotiriou C, Kunkel S, Farmer P, Pradervand S, Haibe-Kains B, Desmedt C, Ignatiadis M, Sengstag T, Schutz F, Goldstein DR, Piccart MJ and Delorenzi M (2008) "Meta-analysis of Gene-Expression Profiles in Breast Cancer: Toward a Unified Understanding of Breast Cancer Sub-typing and Prognosis Signatures", Breast Cancer Research, 10(4):R65.

[Package genefu version 2.26.0 Index]