metapone-package {metapone} | R Documentation

## Conducts pathway test of metabolomics data using a weighted permutation test

### Description

The package conducts pathway testing from untargetted metabolomics data. It requires the user to supply feature-level test results, from case-control testing, regression, or other suitable feature-level tests for the study design. Weights are given to metabolic features based on how many metabolites they could potentially match to. The package can combine positive and negative mode results in pathway tests. The package conducts a permutation test that is based on the hypergeometric test for metabolic pathway analysis.

### Details

The package conducts a weighted hypergeometric test using permutations on metabolomics data. The weights are assigned based on how many metabolites each data feature can match to. The user can tune a parameter to change the penalty for multiple-matched features.

### Author(s)

Tianwei Yu<yutianwei@cuhk.edu.cn>

[Package metapone version 1.0.0 Index]