createDoublets {scDblFinder} | R Documentation

## createDoublets

### Description

Creates artificial doublet cells by combining given pairs of cells

### Usage

    createDoublets(
      x,
      dbl.idx,
      clusters = NULL,
      resamp = 0.5,
      halfSize = 0.5,
      adjustSize = FALSE,
      prefix = "dbl."
    )

### Arguments

`x` | A count matrix of real cells
`dbl.idx` | A matrix or data.frame with pairs of cell indexes stored in the first two columns.
`clusters` | An optional vector of cluster labels (for each column of 'x')
`resamp` | Logical; whether to resample the doublets using the poisson distribution. Alternatively, if a proportion between 0 and 1, the proportion of doublets to resample.
`halfSize` | Logical; whether to half the library size of doublets (instead of just summing up the cells). Alternatively, a number between 0 and 1 can be given, determining the proportion of the doublets for which to perform the size adjustment. Ignored if not resampling.
`adjustSize` | Logical; whether to adjust the size of the doublets using the median sizes per cluster of the originating cells. Requires 'clusters' to be given. Alternatively to a logical value, a number between 0 and 1 can be given, determining the proportion of the doublets for which to perform the size adjustment.
`prefix` | Prefix for the colnames generated.

### Value

A matrix of artificial doublets.

### Examples

    sce <- mockDoubletSCE()
    idx <- getCellPairs(sce$cluster, n=200)
    art.dbls <- createDoublets(sce, idx)

[Package scDblFinder version 1.8.0 Index]