sim.intervention {nem}R Documentation

Simulate interventions in a Nested Effects Model

Description

Simulates a knock-down of a list of network nodes and returns the network nodes and effect reporters, where effects are expected.

Usage

sim.intervention(x, int)

Arguments

x nem object
int a character vector of nodes in the network

Value

list with two slots:

Sgenes.effected effected network nodes
Egenes.effected effected downstream effect reporters

Author(s)

Holger Froehlich

Examples

   data("BoutrosRNAi2002")
   D <- BoutrosRNAiDiscrete[,9:16]
   res = nem(D, control=set.default.parameters(unique(colnames(D)), para=c(0.13,0.05))) 
   sim.intervention(res, "rel") # simulate knock-down of rel

[Package nem version 2.8.0 Index]