betaparametw {MBttest} | R Documentation

## Estimation of proportion weights

### Description

Function betaparametw is used to calculate weight.

### Usage

    betaparametw(xn, a, b)

### Arguments

`xn` | vector of m library sizes. Library size is sum of counts over the whole library.
`a` | parameter alpha in beta distribution derived from output of function betaparametab
`b` | parameter beta in beta distribution derived from output of function betaparametab

### Details

alpha and beta are used to calculate weight. Then weight is in turn used to correct bias of estimation of alpha and beta in betaparametab function.

### Value

return weight(W)

### Author(s)

Yuan-De Tan tanyuande@gmail.com

### References

Baggerly KA, Deng L, Morris JS, Aldaz CM (2003) Differential expression in SAGE: accounting for normal between-library variation. Bioinformatics, 19: 1477-1483.
Yuan-De Tan, Anita M. Chandler, Arindam Chaudhury, and Joel R. Neilson(2015) A Powerful Statistical Approach for Large-scale Differential Transcription Analysis.Plos One. 2015 DOI: 10.1371/journal.pone.0123658.

### See Also

`betaparametab`,`betaparametVP`.

### Examples

    XX<-c(2000,2000,2000)
    a<-1.1458
    b<-6.4932
    betaparametw(xn=XX,a=a,b=b)
    #[1] 0.3333333 0.3333333 0.3333333

[Package MBttest version 1.10.0 Index]