BScore {RNAither} | R Documentation

## BScore normalization

### Description

Normalization with BScores (see References).

### Usage

    BScore(header, dataset, listOfArgs)

### Arguments

`header` | the header of a dataset file generated with `generateDatasetFile`
`dataset` | an R data frame generated with `generateDatasetFile`
`listOfArgs` | a list containing: - a character string specifying the column whose values will be used for normalization - a flag specifying whether controls should be excluded for the computation of the median polish (1) or not (0)

### Value

A list containing:

`header` | The new header (with an added entry about the normalization procedure in the comments)
`dataset` | The new dataset with normalized values. The old values are saved in an extra column of the dataset with the suffix ".old"

### References

C. Brideau, B. Gunter, B. Pikounis, and A. Liaw. Improved statistical methods for hit selection in high-throughput screening. J Biomol Screen, 8:634-647, 2003

### Examples

    data(exampleHeader, package="RNAither")
    data(exampleDataset, package="RNAither")
    normres <- BScore(header, dataset, list("SigIntensity", 0))
    newheader <- normres[[1]]
    newdataset <- normres[[2]]

[Package RNAither version 2.30.1 Index]