ppi_enrichment {STRINGdb} | R Documentation

## ppi_enrichment

### Description

Computes the enrichment in protein-protein interactions.

### Usage

    ppi_enrichment(hitList, ppi_network)

### Arguments

`hitList` | sorted list of proteins (from the most significant to the least significant)
`ppi_network` | an igraph object containing the graph of the protein-protein interaction's network.

### Value

`enrichment` | pvalue that describes the probability to get such a number of interactions by chance
`lambda` | expected number of interactions

### Author(s)

Andrea Franceschini

### References

Pradines JR, Farutin V, Rowley S, Dancik V. Analyzing protein lists with large networks: edge-count probabilities in random graphs with given expected degrees. J. Comput. Biol. 2005;12:113-128. Franceschini, A et al. (2013). STRING v9.1: protein-protein interaction networks, with increased coverage and integration. In:Nucleic Acids Res. 2013 Jan;41(Database issue)

[Package STRINGdb version 1.22.0 Index]