ct.RRAalpha {gCrisprTools} | R Documentation

## Aggregation of P-value Ranks using a Beta Distribution and Alpha Cutoff

### Description

This function is called internally as a single instance of the beta aggregation step in RRAa. Users should not interact with it directly. The expected input is a list of rank statistics, and a paired `alpha` argument defining which values to consider in downstream analyses (see below).

### Usage

    ct.RRAalpha(p, g.key, shuffle = FALSE)

### Arguments

`p` | A single column matrix of rank statistics, with `row.names` indicating the gRNA labels.
`g.key` | data.frame with guide and gene names
`shuffle` | Logical indicating whether to shuffle the rank statistics prior to calculating the rho statistics (useful for permutation).

### Value

Nothing, or a named list of target-level P-values, which are treated as a rho statistic in the permutation step.

### Author(s)

Russell Bainer

### Examples

    data('fit')
    data('ann')
    geneScores <- ct.RRAalpha(fit$p.value, ann, shuffle = FALSE)

[Package gCrisprTools version 1.10.1 Index]