# Signaling Pathway Impact Analysis (SPIA) using combined evidence of pathway over-representation and unusual signaling perturbations

## Documentation for package ‘SPIA’ version 2.12.0

- DESCRIPTION file.
- User guides, package vignettes and other documentation.

## Help Pages

ALL_Colorectal | Results from a microarray experiment comparing colorectal cancer samples and normal tissue samples.
ALL_Vessels | Results from a microarray expriment comparing umbilical veins and arteries tissues
colorectalcancer | Results from a microarray experiment comparing colorectal cancer samples and normal tissue samples.
combfunc | Combining two p-values using Fisher's product or normal inversion method
DE_Colorectal | Results from a microarray experiment comparing colorectal cancer samples and normal tissue samples.
DE_Vessels | Results from a microarray expriment comparing umbilical veins and arteries tissues
makeSPIAdata | Process KGML files for spia analysis
plotP | SPIA two-way evidence plot
spia | Signaling Pathway Impact Analysis (SPIA) based on over-representation and signaling perturbations accumulation
top | Results from a microarray experiment comparing colorectal cancer samples and normal tissue samples.
Vessels | Results from a microarray expriment comparing umbilical veins and arteries tissues