drugInteractions {maftools} | R Documentation

## Drug-Gene Interactions

### Description

Checks for drug-gene interactions and druggable categories

### Usage

    drugInteractions(
      maf,
      top = 20,
      genes = NULL,
      plotType = "bar",
      drugs = FALSE,
      fontSize = 0.8
    )

### Arguments

`maf` | an `MAF` object generated by `read.maf`
`top` | Top number genes to check for. Default 20
`genes` | Manually specify gene list
`plotType` | Can be bar, pie, or wordCloud. Default bar plot.
`drugs` | Check for known/reported drugs. Default FALSE
`fontSize` | Default 0.8

### Details

This function takes a list of genes and checks for known/reported drug-gene interactions or Druggable categories. All gene-drug interactions and drug claims are compiled from Drug Gene Interaction Databse. See reference for details and cite it if you use this function.

### References

Griffith, M., Griffith, O. L., Coffman, A. C., Weible, J. V., McMichael, J. F., Spies, N. C., et. al,. 2013. DGIdb - Mining the druggable genome. Nature Methods.

### Examples

    laml.maf <- system.file("extdata", "tcga_laml.maf.gz", package = "maftools")
    laml <- read.maf(maf = laml.maf)
    drugInteractions(maf = laml)

[Package maftools version 2.2.10 Index]