compareSignatures {maftools} | R Documentation

## Compares identified denovo mutational signatures to known COSMIC signatures

### Description

Takes results from `extractSignatures` and compares them known COSMIC signatures. Two COSMIC databases are used for comparisons - "legacy" which includes 30 signaures, and "SBS" - which includes updated/refined 65 signatures

### Usage

    compareSignatures(nmfRes, sig_db = "legacy", verbose = TRUE)

### Arguments

`nmfRes` | results from `extractSignatures`
`sig_db` | can be `legacy` or `SBS`. Default `legacy`
`verbose` | Default TRUE

### Details

SBS signature database was obtained from https://www.synapse.org/#!Synapse:syn11738319.7

### Value

list containing cosine smilarities, aetiologies if available, and best match.

### See Also

`trinucleotideMatrix` `extractSignatures` `plotSignatures`

[Package maftools version 2.2.10 Index]