# COexpression Tables ANalysis

## Documentation for package ‘COTAN’ version 2.2.3

- DESCRIPTION file.
- User guides, package vignettes and other documentation.
- Package NEWS.

## Help Pages

A C D E F G H I L M N O P R S T U V

## -- A --

addClusterization | Handling cells' _clusterization_ and related functions
addClusterization-method | Handling cells' _clusterization_ and related functions
addClusterizationCoex | Handling cells' _clusterization_ and related functions
addClusterizationCoex-method | Handling cells' _clusterization_ and related functions
addCondition | Handling cells' _conditions_ and related functions
addCondition-method | Handling cells' _conditions_ and related functions
addElementToMetaDataset | Handling _meta-data_ in 'COTAN' objects
addElementToMetaDataset-method | Handling _meta-data_ in 'COTAN' objects
automaticCOTANObjectCreation | Automatic 'COTAN' shortcuts

## -- C --

calculateCoex | Calculating the COEX matrix for genes and cells
calculateCoex-method | Calculating the COEX matrix for genes and cells
calculateG | Calculating the COEX matrix for genes and cells
calculateGDI | Calculations of genes statistics
calculateGenesCE | Calculations of genes statistics
calculateMu | Calculating the COEX matrix for genes and cells
calculateMu-method | Calculating the COEX matrix for genes and cells
calculatePDI | Calculations of genes statistics
calculatePValue | Calculations of genes statistics
calculateS | Calculating the COEX matrix for genes and cells
CalculatingCOEX | Calculating the COEX matrix for genes and cells
cellsHeatmapPlot | Heatmap Plots
cellSizePlot | Raw data cleaning
cellsUniformClustering | Uniform Clusters
checkClusterUniformity | Uniform Clusters
clean | Raw data cleaning
clean-method | Raw data cleaning
cleanPlots | Raw data cleaning
clustersDeltaExpression | Handling cells' _clusterization_ and related functions
ClustersList | _Clusters_ utilities
clustersMarkersHeatmapPlot | Handling cells' _clusterization_ and related functions
clustersSummaryData | Handling cells' _clusterization_ and related functions
clustersSummaryPlot | Handling cells' _clusterization_ and related functions
clustersTreePlot | Handling cells' _clusterization_ and related functions
contingencyTables | Calculating the COEX matrix for genes and cells
COTAN | COTAN
COTAN-class | Definition of the 'COTAN' class
COTANObjectCreation | Automatic 'COTAN' shortcuts

## -- D --

Datasets | Data-sets
datasetTags | Handling _meta-data_ in 'COTAN' objects
DEAOnClusters | Handling cells' _clusterization_ and related functions
dropCellsCoex | Calculating the COEX matrix for genes and cells
dropCellsCoex-method | Calculating the COEX matrix for genes and cells
dropClusterization | Handling cells' _clusterization_ and related functions
dropClusterization-method | Handling cells' _clusterization_ and related functions
dropCondition | Handling cells' _conditions_ and related functions
dropCondition-method | Handling cells' _conditions_ and related functions
dropGenesCells | Raw data cleaning
dropGenesCells-method | Raw data cleaning
dropGenesCoex | Calculating the COEX matrix for genes and cells
dropGenesCoex-method | Calculating the COEX matrix for genes and cells

## -- E --

ECDPlot | Raw data cleaning
ERCCraw | Data-sets
establishGenesClusters | Local Differentiation Index
estimateDispersionBisection | Estimation of the 'COTAN' model's parameters
estimateDispersionBisection-method | Estimation of the 'COTAN' model's parameters
estimateDispersionNuBisection | Estimation of the 'COTAN' model's parameters
estimateDispersionNuBisection-method | Estimation of the 'COTAN' model's parameters
estimateDispersionNuNlminb-method | Estimation of the 'COTAN' model's parameters
estimateLambdaLinear | Estimation of the 'COTAN' model's parameters
estimateLambdaLinear-method | Estimation of the 'COTAN' model's parameters
estimateNuBisection-method | Estimation of the 'COTAN' model's parameters
estimateNuLinear | Estimation of the 'COTAN' model's parameters
estimateNuLinear-method | Estimation of the 'COTAN' model's parameters
estimateNuLinearByCluster | Handling cells' _clusterization_ and related functions
estimateNuLinearByCluster-method | Handling cells' _clusterization_ and related functions
expectedContingencyTables | Calculating the COEX matrix for genes and cells
expectedContingencyTablesNN | Calculating the COEX matrix for genes and cells

## -- F --

findClustersMarkers | Handling cells' _clusterization_ and related functions
findFullyExpressedGenes | Raw data cleaning
findFullyExpressedGenes-method | Raw data cleaning
findFullyExpressingCells | Raw data cleaning
findFullyExpressingCells-method | Raw data cleaning
flagNotFullyExpressedGenes | Raw data cleaning
flagNotFullyExpressedGenes-method | Raw data cleaning
flagNotFullyExpressingCells | Raw data cleaning
flagNotFullyExpressingCells-method | Raw data cleaning
fromClustersList | _Clusters_ utilities
funProbZero | funProbZero

## -- G --

GDIPlot | Uniform Clusters
GenesCoexSpace | Local Differentiation Index
genesCoexSpace | Local Differentiation Index
geneSetEnrichment | Handling cells' _clusterization_ and related functions
genesHeatmapPlot | Heatmap Plots
genesSizePlot | Raw data cleaning
GenesStatistics | Calculations of genes statistics
getAllConditions | Handling cells' _conditions_ and related functions
getAllConditions-method | Handling cells' _conditions_ and related functions
getCells | Raw data 'COTAN' accessors
getCells-method | Raw data 'COTAN' accessors
getCellsCoex | Calculating the COEX matrix for genes and cells
getCellsCoex-method | Calculating the COEX matrix for genes and cells
getCellsSize | Raw data 'COTAN' accessors
getCellsSize-method | Raw data 'COTAN' accessors
getClusterizationData | Handling cells' _clusterization_ and related functions
getClusterizationData-method | Handling cells' _clusterization_ and related functions
getClusterizationName | Handling cells' _clusterization_ and related functions
getClusterizationName-method | Handling cells' _clusterization_ and related functions
getClusterizations | Handling cells' _clusterization_ and related functions
getClusterizations-method | Handling cells' _clusterization_ and related functions
getClusters | Handling cells' _clusterization_ and related functions
getClustersCoex | Handling cells' _clusterization_ and related functions
getClustersCoex-method | Handling cells' _clusterization_ and related functions
getColorsVector | getColorsVector
getCondition | Handling cells' _conditions_ and related functions
getCondition-method | Handling cells' _conditions_ and related functions
getConditionName | Handling cells' _conditions_ and related functions
getConditionName-method | Handling cells' _conditions_ and related functions
getDims | Handling _meta-data_ in 'COTAN' objects
getDims-method | Handling _meta-data_ in 'COTAN' objects
getDispersion | Estimation of the 'COTAN' model's parameters
getDispersion-method | Estimation of the 'COTAN' model's parameters
getFullyExpressedGenes | Raw data cleaning
getFullyExpressedGenes-method | Raw data cleaning
getFullyExpressingCells | Raw data cleaning
getFullyExpressingCells-method | Raw data cleaning
getGenes | Raw data 'COTAN' accessors
getGenes-method | Raw data 'COTAN' accessors
getGenesCoex | Calculating the COEX matrix for genes and cells
getGenesCoex-method | Calculating the COEX matrix for genes and cells
getGenesSize | Raw data 'COTAN' accessors
getGenesSize-method | Raw data 'COTAN' accessors
getLambda | Estimation of the 'COTAN' model's parameters
getLambda-method | Estimation of the 'COTAN' model's parameters
getMetadataCells | Handling _meta-data_ in 'COTAN' objects
getMetadataCells-method | Handling _meta-data_ in 'COTAN' objects
getMetadataDataset | Handling _meta-data_ in 'COTAN' objects
getMetadataDataset-method | Handling _meta-data_ in 'COTAN' objects
getMetadataElement | Handling _meta-data_ in 'COTAN' objects
getMetadataElement-method | Handling _meta-data_ in 'COTAN' objects
getMetadataGenes | Handling _meta-data_ in 'COTAN' objects
getMetadataGenes-method | Handling _meta-data_ in 'COTAN' objects
getNormalizedData | Estimation of the 'COTAN' model's parameters
getNormalizedData-method | Estimation of the 'COTAN' model's parameters
getNu | Estimation of the 'COTAN' model's parameters
getNu-method | Estimation of the 'COTAN' model's parameters
getNumCells | Raw data 'COTAN' accessors
getNumCells-method | Raw data 'COTAN' accessors
getNumExpressedGenes | Raw data 'COTAN' accessors
getNumExpressedGenes-method | Raw data 'COTAN' accessors
getNumGenes | Raw data 'COTAN' accessors
getNumGenes-method | Raw data 'COTAN' accessors
getNumOfExpressingCells | Raw data 'COTAN' accessors
getNumOfExpressingCells-method | Raw data 'COTAN' accessors
getRawData | Raw data 'COTAN' accessors
getRawData-method | Raw data 'COTAN' accessors
getZeroOneProj | Raw data 'COTAN' accessors
getZeroOneProj-method | Raw data 'COTAN' accessors
groupByClusters | _Clusters_ utilities
groupByClustersList | _Clusters_ utilities

## -- H --

HandleMetaData | Handling _meta-data_ in 'COTAN' objects
HandlingClusterizations | Handling cells' _clusterization_ and related functions
HandlingConditions | Handling cells' _conditions_ and related functions
heatmapPlot | Heatmap Plots
HeatmapPlots | Heatmap Plots

## -- I --

initializeMetaDataset | Handling _meta-data_ in 'COTAN' objects
initializeMetaDataset-method | Handling _meta-data_ in 'COTAN' objects

## -- L --

LegacyFastSymmMatrix | Handle symmetric matrix <-> vector conversions
LoggingFunctions | Logging in the 'COTAN' package
logThis | Logging in the 'COTAN' package

## -- M --

mat2vec_rfast | Handle symmetric matrix <-> vector conversions
mergeClusters | _Clusters_ utilities
mergeUniformCellsClusters | Uniform Clusters
mitochondrialPercentagePlot | Raw data cleaning
multiMergeClusters | _Clusters_ utilities

## -- N --

normalizeNameAndLabels | Handling cells' _conditions_ and related functions

## -- O --

observedContingencyTables | Calculating the COEX matrix for genes and cells
observedContingencyTablesYY | Calculating the COEX matrix for genes and cells

## -- P --

ParametersEstimations | Estimation of the 'COTAN' model's parameters
plotTheme | Heatmap Plots
proceedToCoex | Automatic 'COTAN' shortcuts
proceedToCoex-method | Automatic 'COTAN' shortcuts
pValueFromDEA | Handling cells' _clusterization_ and related functions

## -- R --

raw.dataset | Data-sets
RawDataCleaning | Raw data cleaning
RawDataGetters | Raw data 'COTAN' accessors
reorderClusterization | Handling cells' _clusterization_ and related functions

## -- S --

scatterPlot | Raw data cleaning
scCOTAN | scCOTAN-class (for legacy usage)
scCOTAN-class | scCOTAN-class (for legacy usage)
setColumnInDF | Handling _meta-data_ in 'COTAN' objects
setLoggingFile | Logging in the 'COTAN' package
setLoggingLevel | Logging in the 'COTAN' package

## -- T --

test.dataset | Data-sets
test.dataset.clusters1 | Data-sets
test.dataset.clusters2 | Data-sets
toClustersList | _Clusters_ utilities

## -- U --

UMAPPlot | Handling cells' _clusterization_ and related functions
UniformClusters | Uniform Clusters

## -- V --

vec2mat_rfast | Handle symmetric matrix <-> vector conversions