# Integration of Disease Similarity Methods

\ Min Li ()\ Peng Ni ()\ School of Information Science and Engineering, Central South University, Changsha, 410083, China.

#### 2017-10-30

# Contents

# 1 Abstract

Discovering disease-disease simialrties can be useful for us to inferring the mechanisms of complex diseases. Disease similarity has become the important basis in disease-related molecular function research. There have been a number of methods proposed for measuring disease similarity in recent years. But there are lacks of tools or web servers for the computation of these methods. We present an R package dSimer which provides computation of nine methods for measuring disease-disease similarity, including a standard cosine similarity measure and eight function-based methods. The disease similarity matrix obtained from these nine methods can be visualized through heatmap and network. Biological data widely used in disease-disease associations study are also provided by dSimer.

# 2 Introduction

The quantification of similarity among diseases has drawn more and more attention in modern biology and medicine. Understanding similarity among diseases can not only help us gain deeper insights into complex diseases, but also lead to improvements in disease diagnosis, drug repurposing and new drug development. Due to the growing body of high-throughput biological data such as genomic and proteomic data, a number of methods have been proposed for the computation of similarity among diseases during the past decade.

Here we present dSimer for the calculation of nine disease similarity methods, including one standard cosine similarity method [1, 2] and eight function-based methods which compare disease-related gene set for calculating [3]. Besides, we also implemented methods for the visualization of disease similarity matrix.

To start with dSimer package, type following codes below:

    library(dSimer)
    help("dSimer")

# 3 The standard cosine similarity method

The cosine similarity method is a widely used standard measure in disease association analyses [1, 2]. First it constructs feature vectors for diseases from literature or by using other biological data. Then it calculate the cosine of the angle between normalized vector pairs as the similarity scores between diseases. We implemented function CosineDFV for this method:

    data(d2s_hsdn) #get disease-symptom associations for constructing feature vectors
    ds <- sample(unique(d2s_hsdn[,2]), 5) #get disease names sample
    simmat <- CosineDFV(ds, ds, d2s_hsdn)
    simmat

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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Pleural Neoplasms
    ## Pleural Neoplasms                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   1.000000000
    ## Muscular Disorders, Atrophic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        0.005945882
    ## Meningomyelocele                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    0.002155779
    ## Sjogrens Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGastroesophageal Reflux\t1\t3.543332367391082\nUrinary Bladder, Overactive\tColitis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIntestinal Pseudo-Obstruction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFecal Incontinence\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLiver Cirrhosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tXerostomia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Apnea Syndromes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCough\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Acute Disseminated\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple Sclerosis\t19\t67.32331498043055\nUrinary Bladder, Overactive\tMyasthenia Gravis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Autoimmune, Experimental\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAutonomic Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple System Atrophy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCentral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParkinson Disease\t8\t28.346658939128655\nUrinary Bladder, Overactive\tCerebral Palsy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Ischemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCerebral Infarction\t6\t21.25999420434649\nUrinary Bladder, Overactive\tInfarction, Middle Cerebral Artery\t2\t7.086664734782164\nUrinary Bladder, Overactive\tStroke\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDementia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tAlzheimer Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHydrocephalus, Normal Pressure\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHyperprolactinemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMovement Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEssential Tremor\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSpinal Cord Diseases\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSpinal Cord Injuries\t26\t92.12664155216812\nUrinary Bladder, Overactive\tMeningomyelocele\t4\t14.173329469564328\nUrinary Bladder, Overactive\tSpinal Dysraphism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAmyloid Neuropathies, Familial\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAtaxia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDelirium\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSyncope\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMemory Disorders\t4\t14.173329469564328\nUrinary Bladder, Overactive\tNeurogenic Inflammation\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMuscle Hypertonia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPain\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPain, Intractable\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParaplegia\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperesthesia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Neurogenic\t91\t322.44324543258847\nUrinary Bladder, Overactive\tPeripheral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetic Neuropathies\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Disorders, Intrinsic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tRestless Legs Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGlaucoma\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Hyperplasia\t49\t173.623286002163\nUrinary Bladder, Overactive\tProstatitis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSexual Dysfunction, Physiological\t10\t35.43332367391082\nUrinary Bladder, Overactive\tErectile Dysfunction\t8\t28.346658939128655\nUrinary Bladder, Overactive\tImpotence, Vasculogenic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrologic Diseases\t21\t74.40997971521271\nUrinary Bladder, Overactive\tUreteral Calculi\t2\t7.086664734782164\nUrinary Bladder, Overactive\tUrethral Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrethral Obstruction\t3\t10.629997102173245\nUrinary Bladder, Overactive\tUrinary Bladder Neck Obstruction\t41\t145.27662706303437\nUrinary Bladder, Overactive\tUrinary Bladder Diseases\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis, Interstitial\t27\t95.66997391955921\nUrinary Bladder, Overactive\tCystocele\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Overactive\t1194\t4230.738846664952\nUrinary Bladder, Overactive\tVesico-Ureteral Reflux\t7\t24.803326571737575\nUrinary Bladder, Overactive\tUrination Disorders\t42\t148.81995943042543\nUrinary Bladder, Overactive\tEnuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tNocturnal Enuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHematuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPolyuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Incontinence\t151\t535.0431874760534\nUrinary Bladder, Overactive\tUrinary Incontinence, Stress\t48\t170.07995363477193\nUrinary Bladder, Overactive\tUrinary Incontinence, Urge\t69\t244.48993334998465\nUrinary Bladder, Overactive\tUrinary Retention\t20\t70.86664734782164\nUrinary Bladder, Overactive\tFemale Urogenital Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFallopian Tube Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEndometriosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Prolapse\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPregnancy Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor, Premature\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPuerperal Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHeart Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLong QT Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tTorsades de Pointes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMyocardial Infarction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHypertension\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDrug Eruptions\t2\t7.086664734782164\nUrinary Bladder, Overactive\tLichenoid Eruptions\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHyperhidrosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCalcinosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus, Experimental\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Mellitus, Type 2\t2\t7.086664734782164\nUrinary Bladder, Overactive\tMetabolic Syndrome X\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperlipidemias\t2\t7.086664734782164\nUrinary Bladder, Overactive\tObesity\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Complications\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHypogonadism\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHypersensitivity\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCognition Disorders\t8\t28.346658939128655\nUrinary Bladder, Overactive\tSexual Dysfunctions, Psychological\t2\t7.086664734782164\nUrinary Bladder, Overactive\tTranssexualism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPelvic Organ Prolapse\t7\t24.803326571737575\nUrinary Bladder, Overactive\tGenetic Predisposition to Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCicatrix\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIschemia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tNerve Degeneration\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPostoperative Complications\t6\t21.25999420434649\nUrinary Incontinence\tBacterial Infections\t6\t9.705176049809179\nUrinary Incontinence\tBacteremia\t1\t1.6175293416348633\nUrinary Incontinence\tEpidural Abscess\t2\t3.2350586832697266\nUrinary Incontinence\tNeurosyphilis\t5\t8.087646708174317\nUrinary Incontinence\tFournier Gangrene\t1\t1.6175293416348633\nUrinary Incontinence\tLyme Disease\t2\t3.2350586832697266\nUrinary Incontinence\tMelioidosis\t1\t1.6175293416348633\nUrinary Incontinence\tChlamydia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEnterobacteriaceae Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEscherichia coli Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHelicobacter Infections\t1\t1.6175293416348633\nUrinary Incontinence\tPseudomonas Infections\t2\t3.2350586832697266\nUrinary Incontinence\tBoutonneuse Fever\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculoma\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Miliary\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Spinal\t2\t3.2350586832697266\nUrinary Incontinence\tTuberculosis, Urogenital\t3\t4.852588024904589\nUrinary Incontinence\tNocardia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStaphylococcal Infections\t2\t3.2350586832697266\nUrinary Incontinence\tStaphylococcal Skin Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStreptococcal Infections\t1\t1.6175293416348633\nUrinary Incontinence\tInfection\t1\t1.6175293416348633\nUrinary Incontinence\tOsteitis\t2\t3.2350586832697266\nUrinary Incontinence\tOsteomyelitis\t4\t6.470117366539453\nUrinary Incontinence\tSpondylitis\t1\t1.6175293416348633\nUrinary Incontinence\tCommunicable Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tCommunity-Acquired Infections\t1\t1.6175293416348633\nUrinary Incontinence\tCross Infection\t3\t4.852588024904589\nUrinary Incontinence\tAIDS-Related Opportunistic Infections\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Infection\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Inflammatory Disease\t1\t1.6175293416348633\nUrinary Incontinence\tPregnancy Complications, Infectious\t1\t1.6175293416348633\nUrinary Incontinence\tProsthesis-Related Infections\t5\t8.087646708174317\nUrinary Incontinence\tRespiratory Tract Infections\t2\t3.2350586832697266\nUrinary Incontinence\tSepsis\t1\t1.6175293416348633\nUrinary Incontinence\tSexually Transmitted Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tAbscess\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tLiver Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tUrinary Tract Infections\t118\t190.86846231291386\nUrinary Incontinence\tBacteriuria\t26\t42.05576288250644\nUrinary Incontinence\tPyuria\t2\t3.2350586832697266\nUrinary Incontinence\tWound Infection\t1\t1.6175293416348633\nUrinary Incontinence\tSurgical Wound Infection\t2\t3.2350586832697266\nUrinary Incontinence\tAspergillosis\t1\t1.6175293416348633\nUrinary Incontinence\tCandidiasis\t3\t4.852588024904589\nUrinary Incontinence\tMeningitis, Cryptococcal\t1\t1.6175293416348633\nUrinary Incontinence\tHistoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tWest Nile Fever\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Viral\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Herpes Simplex\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis\t5\t8.087646708174317\nUrinary Incontinence\tParaparesis, Tropical Spastic\t4\t6.470117366539453\nUrinary Incontinence\tChickenpox\t3\t4.852588024904589\nUrinary Incontinence\tCytomegalovirus Infections\t1\t1.6175293416348633\nUrinary Incontinence\tBurkitt Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Genitalis\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Zoster\t4\t6.470117366539453\nUrinary Incontinence\tCondylomata Acuminata\t1\t1.6175293416348633\nUrinary Incontinence\tDistemper\t1\t1.6175293416348633\nUrinary Incontinence\tMumps\t1\t1.6175293416348633\nUrinary Incontinence\tCommon Cold\t2\t3.2350586832697266\nUrinary Incontinence\tHTLV-I Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHTLV-II Infections\t2\t3.2350586832697266\nUrinary Incontinence\tHIV Infections\t1\t1.6175293416348633\nUrinary Incontinence\tAcquired Immunodeficiency Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tAIDS Dementia Complex\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroschistosomiasis\t1\t1.6175293416348633\nUrinary Incontinence\tEchinococcosis\t2\t3.2350586832697266\nUrinary Incontinence\tOxyuriasis\t1\t1.6175293416348633\nUrinary Incontinence\tStrongyloidiasis\t1\t1.6175293416348633\nUrinary Incontinence\tSchistosomiasis\t2\t3.2350586832697266\nUrinary Incontinence\tSchistosomiasis mansoni\t2\t3.2350586832697266\nUrinary Incontinence\tToxoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tCysts\t11\t17.792822757983497\nUrinary Incontinence\tArachnoid Cysts\t3\t4.852588024904589\nUrinary Incontinence\tBone Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tDermoid Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tEpidermal Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tLymphocele\t1\t1.6175293416348633\nUrinary Incontinence\tOvarian Cysts\t2\t3.2350586832697266\nUrinary Incontinence\tHamartoma\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Lymphoid\t1\t1.6175293416348633\nUrinary Incontinence\tPrecursor Cell Lymphoblastic Leukemia-Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Myeloid, Acute\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia, Monocytic, Acute\t1\t1.6175293416348633\nUrinary Incontinence\tSarcoma, Myeloid\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHodgkin Disease\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Non-Hodgkin\t2\t3.2350586832697266\nUrinary Incontinence\tLymphoma, B-Cell\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, AIDS-Related\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Large B-Cell, Diffuse\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, Large-Cell, Immunoblastic\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Adenosquamous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinosarcoma\t1\t1.6175293416348633\nUrinary Incontinence\tAngiolipoma\t2\t3.2350586832697266\nUrinary Incontinence\tLipoma\t11\t17.792822757983497\nUrinary Incontinence\tGiant Cell Tumor of Bone\t1\t1.6175293416348633\nUrinary Incontinence\tFibroma\t1\t1.6175293416348633\nUrinary Incontinence\tFibromatosis, Aggressive\t1\t1.6175293416348633\nUrinary Incontinence\tBrenner Tumor\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Muscle Tissue\t1\t1.6175293416348633\nUrinary Incontinence\tLeiomyoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma, Embryonal\t1\t1.6175293416348633\nUrinary Incontinence\tChordoma\t2\t3.2350586832697266\nUrinary Incontinence\tGerminoma\t2\t3.2350586832697266\nUrinary Incontinence\tDysgerminoma\t1\t1.6175293416348633\nUrinary Incontinence\tCraniopharyngioma\t1\t1.6175293416348633\nUrinary Incontinence\tGlioma\t2\t3.2350586832697266\nUrinary Incontinence\tGlioblastoma\t3\t4.852588024904589\nUrinary Incontinence\tEpendymoma\t2\t3.2350586832697266\nUrinary Incontinence\tGanglioglioma\t1\t1.6175293416348633\nUrinary Incontinence\tOligodendroglioma\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroblastoma\t3\t4.852588024904589\nUrinary Incontinence\tNeuroendocrine Tumors\t1\t1.6175293416348633\nUrinary Incontinence\tMelanoma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurilemmoma\t5\t8.087646708174317\nUrinary Incontinence\tParaganglioma\t1\t1.6175293416348633\nUrinary Incontinence\tTeratoma\t2\t3.2350586832697266\nUrinary Incontinence\tChoriocarcinoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Islet Cell\t1\t1.6175293416348633\nUrinary Incontinence\tSyringoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Villous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma\t10\t16.175293416348634\nUrinary Incontinence\tAdenocarcinoma\t32\t51.760938932315625\nUrinary Incontinence\tAdenocarcinoma, Clear Cell\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Follicular\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Mucinous\t1\t1.6175293416348633\nUrinary Incontinence\tLinitis Plastica\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Ductal, Breast\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Lobular\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Signet Ring Cell\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Intraepithelial Neoplasia\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Small Cell\t2\t3.2350586832697266\nUrinary Incontinence\tCarcinoma, Squamous Cell\t5\t8.087646708174317\nUrinary Incontinence\tCarcinoma, Transitional Cell\t5\t8.087646708174317\nUrinary Incontinence\tMeningioma\t5\t8.087646708174317\nUrinary Incontinence\tNeurofibroma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatoses\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatosis 1\t3\t4.852588024904589\nUrinary Incontinence\tMultiple Myeloma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma\t2\t3.2350586832697266\nUrinary Incontinence\tHemangioendothelioma, Epithelioid\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioblastoma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma, Cavernous\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tPeritoneal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRetroperitoneal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tAnal Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBone Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSkull Base Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tBreast Neoplasms\t9\t14.55776407471377\nUrinary Incontinence\tIntestinal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColorectal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColonic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRectal Neoplasms\t10\t16.175293416348634\nUrinary Incontinence\tAnus Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tOvarian Neoplasms\t7\t11.322705391444043\nUrinary Incontinence\tPituitary Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tTesticular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tThyroid Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tNasopharyngeal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBrain Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tCerebral Ventricle Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tInfratentorial Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCerebellar Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tHypothalamic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCentral Nervous System Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tMeningeal Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tMeningeal Carcinomatosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Cord Neoplasms\t20\t32.35058683269727\nUrinary Incontinence\tEpidural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis, Transverse\t5\t8.087646708174317\nUrinary Incontinence\tParaneoplastic Cerebellar Degeneration\t1\t1.6175293416348633\nUrinary Incontinence\tParaneoplastic Polyneuropathy\t1\t1.6175293416348633\nUrinary Incontinence\tPeripheral Nervous System Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPelvic Neoplasms\t6\t9.705176049809179\nUrinary Incontinence\tSweat Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tVascular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tLung Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPleural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrogenital Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Female\t7\t11.322705391444043\nUrinary Incontinence\tFallopian Tube Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tUterine Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tEndometrial Neoplasms\t4\t6.470117366539453\nUrinary Incontinence\tUterine Cervical Neoplasms\t17\t27.497998807792676\nUrinary Incontinence\tVaginal Neoplasms\t12\t19.410352099618358\nUrinary Incontinence\tVulvar Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Male\t1\t1.6175293416348633\nUrinary Incontinence\tPenile Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Neoplasms\t224\t362.32657252620936\nUrinary Incontinence\tUrologic Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tUreteral Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrethral Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tUrinary Bladder Neoplasms\t31\t50.14340959068076\nUrinary Incontinence\tNeoplasms, Multiple Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Second Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasm Invasiveness\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Unknown Primary\t2\t3.2350586832697266\nUrinary Incontinence\tNeoplasm Recurrence, Local\t10\t16.175293416348634\nUrinary Incontinence\tParaneoplastic Syndromes\t2\t3.2350586832697266\nUrinary Incontinence\tPregnancy Complications, Neoplastic\t1\t1.6175293416348633\nUrinary Incontinence\tBone Diseases, Developmental\t2\t3.2350586832697266\nUrinary Incontinence\tAchondroplasia\t1\t1.6175293416348633\nUrinary Incontinence\tKlippel-Feil Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tRubinstein-Taybi Syndrome\t1\t1.6175293416348633\nUrinary Incontinence\tMarfan Syndrome\t4\t6.470117366539453\nUrinary Incontinence\tPlatybasia\t1\t1.6175293416348633\nUrinary Incontinence\tOsteoporosis\t6\t9.705176049809179\nUrinary Incontinence\tOsteoporosis, Postmenopausal\t2\t3.2350586832697266\nUrinary Incontinence\tOsteitis Deformans\t2\t3.2350586832697266\nUrinary Incontinence\tSpinal Diseases\t6\t9.705176049809179\nUrinary Incontinence\tIntervertebral Disk Displacement\t11\t17.792822757983497\nUrinary Incontinence\tSpinal Osteophytosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Stenosis\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis, Psoriatic\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolysis\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolisthesis\t1\t1.6175293416348633\nUrinary Incontinence\tClubfoot\t1\t1.6175293416348633\nUrinary Incontinence\tGranuloma, Giant Cell\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis\t3\t4.852588024904589\nUrinary Incontinence\tArthritis, Rheumatoid\t2\t3.2350586832697266\nUrinary Incontinence\tSjogrens Syndrome       0.000000000
    ## Pasteurellosis, Pneumonic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         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    ##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Muscular Disorders, Atrophic
    ## Pleural Neoplasms                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              0.005945882
    ## Muscular Disorders, Atrophic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   1.000000000
    ## Meningomyelocele                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               0.011929046
    ## Sjogrens Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGastroesophageal Reflux\t1\t3.543332367391082\nUrinary Bladder, Overactive\tColitis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIntestinal Pseudo-Obstruction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFecal Incontinence\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLiver Cirrhosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tXerostomia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Apnea Syndromes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCough\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Acute Disseminated\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple Sclerosis\t19\t67.32331498043055\nUrinary Bladder, Overactive\tMyasthenia Gravis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Autoimmune, Experimental\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAutonomic Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple System Atrophy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCentral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParkinson Disease\t8\t28.346658939128655\nUrinary Bladder, Overactive\tCerebral Palsy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Ischemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCerebral Infarction\t6\t21.25999420434649\nUrinary Bladder, Overactive\tInfarction, Middle Cerebral Artery\t2\t7.086664734782164\nUrinary Bladder, Overactive\tStroke\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDementia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tAlzheimer Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHydrocephalus, Normal Pressure\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHyperprolactinemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMovement Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEssential Tremor\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSpinal Cord Diseases\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSpinal Cord Injuries\t26\t92.12664155216812\nUrinary Bladder, Overactive\tMeningomyelocele\t4\t14.173329469564328\nUrinary Bladder, Overactive\tSpinal Dysraphism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAmyloid Neuropathies, Familial\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAtaxia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDelirium\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSyncope\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMemory Disorders\t4\t14.173329469564328\nUrinary Bladder, Overactive\tNeurogenic Inflammation\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMuscle Hypertonia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPain\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPain, Intractable\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParaplegia\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperesthesia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Neurogenic\t91\t322.44324543258847\nUrinary Bladder, Overactive\tPeripheral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetic Neuropathies\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Disorders, Intrinsic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tRestless Legs Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGlaucoma\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Hyperplasia\t49\t173.623286002163\nUrinary Bladder, Overactive\tProstatitis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSexual Dysfunction, Physiological\t10\t35.43332367391082\nUrinary Bladder, Overactive\tErectile Dysfunction\t8\t28.346658939128655\nUrinary Bladder, Overactive\tImpotence, Vasculogenic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrologic Diseases\t21\t74.40997971521271\nUrinary Bladder, Overactive\tUreteral Calculi\t2\t7.086664734782164\nUrinary Bladder, Overactive\tUrethral Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrethral Obstruction\t3\t10.629997102173245\nUrinary Bladder, Overactive\tUrinary Bladder Neck Obstruction\t41\t145.27662706303437\nUrinary Bladder, Overactive\tUrinary Bladder Diseases\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis, Interstitial\t27\t95.66997391955921\nUrinary Bladder, Overactive\tCystocele\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Overactive\t1194\t4230.738846664952\nUrinary Bladder, Overactive\tVesico-Ureteral Reflux\t7\t24.803326571737575\nUrinary Bladder, Overactive\tUrination Disorders\t42\t148.81995943042543\nUrinary Bladder, Overactive\tEnuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tNocturnal Enuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHematuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPolyuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Incontinence\t151\t535.0431874760534\nUrinary Bladder, Overactive\tUrinary Incontinence, Stress\t48\t170.07995363477193\nUrinary Bladder, Overactive\tUrinary Incontinence, Urge\t69\t244.48993334998465\nUrinary Bladder, Overactive\tUrinary Retention\t20\t70.86664734782164\nUrinary Bladder, Overactive\tFemale Urogenital Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFallopian Tube Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEndometriosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Prolapse\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPregnancy Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor, Premature\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPuerperal Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHeart Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLong QT Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tTorsades de Pointes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMyocardial Infarction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHypertension\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDrug Eruptions\t2\t7.086664734782164\nUrinary Bladder, Overactive\tLichenoid Eruptions\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHyperhidrosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCalcinosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus, Experimental\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Mellitus, Type 2\t2\t7.086664734782164\nUrinary Bladder, Overactive\tMetabolic Syndrome X\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperlipidemias\t2\t7.086664734782164\nUrinary Bladder, Overactive\tObesity\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Complications\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHypogonadism\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHypersensitivity\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCognition Disorders\t8\t28.346658939128655\nUrinary Bladder, Overactive\tSexual Dysfunctions, Psychological\t2\t7.086664734782164\nUrinary Bladder, Overactive\tTranssexualism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPelvic Organ Prolapse\t7\t24.803326571737575\nUrinary Bladder, Overactive\tGenetic Predisposition to Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCicatrix\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIschemia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tNerve Degeneration\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPostoperative Complications\t6\t21.25999420434649\nUrinary Incontinence\tBacterial Infections\t6\t9.705176049809179\nUrinary Incontinence\tBacteremia\t1\t1.6175293416348633\nUrinary Incontinence\tEpidural Abscess\t2\t3.2350586832697266\nUrinary Incontinence\tNeurosyphilis\t5\t8.087646708174317\nUrinary Incontinence\tFournier Gangrene\t1\t1.6175293416348633\nUrinary Incontinence\tLyme Disease\t2\t3.2350586832697266\nUrinary Incontinence\tMelioidosis\t1\t1.6175293416348633\nUrinary Incontinence\tChlamydia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEnterobacteriaceae Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEscherichia coli Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHelicobacter Infections\t1\t1.6175293416348633\nUrinary Incontinence\tPseudomonas Infections\t2\t3.2350586832697266\nUrinary Incontinence\tBoutonneuse Fever\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculoma\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Miliary\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Spinal\t2\t3.2350586832697266\nUrinary Incontinence\tTuberculosis, Urogenital\t3\t4.852588024904589\nUrinary Incontinence\tNocardia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStaphylococcal Infections\t2\t3.2350586832697266\nUrinary Incontinence\tStaphylococcal Skin Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStreptococcal Infections\t1\t1.6175293416348633\nUrinary Incontinence\tInfection\t1\t1.6175293416348633\nUrinary Incontinence\tOsteitis\t2\t3.2350586832697266\nUrinary Incontinence\tOsteomyelitis\t4\t6.470117366539453\nUrinary Incontinence\tSpondylitis\t1\t1.6175293416348633\nUrinary Incontinence\tCommunicable Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tCommunity-Acquired Infections\t1\t1.6175293416348633\nUrinary Incontinence\tCross Infection\t3\t4.852588024904589\nUrinary Incontinence\tAIDS-Related Opportunistic Infections\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Infection\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Inflammatory Disease\t1\t1.6175293416348633\nUrinary Incontinence\tPregnancy Complications, Infectious\t1\t1.6175293416348633\nUrinary Incontinence\tProsthesis-Related Infections\t5\t8.087646708174317\nUrinary Incontinence\tRespiratory Tract Infections\t2\t3.2350586832697266\nUrinary Incontinence\tSepsis\t1\t1.6175293416348633\nUrinary Incontinence\tSexually Transmitted Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tAbscess\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tLiver Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tUrinary Tract Infections\t118\t190.86846231291386\nUrinary Incontinence\tBacteriuria\t26\t42.05576288250644\nUrinary Incontinence\tPyuria\t2\t3.2350586832697266\nUrinary Incontinence\tWound Infection\t1\t1.6175293416348633\nUrinary Incontinence\tSurgical Wound Infection\t2\t3.2350586832697266\nUrinary Incontinence\tAspergillosis\t1\t1.6175293416348633\nUrinary Incontinence\tCandidiasis\t3\t4.852588024904589\nUrinary Incontinence\tMeningitis, Cryptococcal\t1\t1.6175293416348633\nUrinary Incontinence\tHistoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tWest Nile Fever\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Viral\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Herpes Simplex\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis\t5\t8.087646708174317\nUrinary Incontinence\tParaparesis, Tropical Spastic\t4\t6.470117366539453\nUrinary Incontinence\tChickenpox\t3\t4.852588024904589\nUrinary Incontinence\tCytomegalovirus Infections\t1\t1.6175293416348633\nUrinary Incontinence\tBurkitt Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Genitalis\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Zoster\t4\t6.470117366539453\nUrinary Incontinence\tCondylomata Acuminata\t1\t1.6175293416348633\nUrinary Incontinence\tDistemper\t1\t1.6175293416348633\nUrinary Incontinence\tMumps\t1\t1.6175293416348633\nUrinary Incontinence\tCommon Cold\t2\t3.2350586832697266\nUrinary Incontinence\tHTLV-I Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHTLV-II Infections\t2\t3.2350586832697266\nUrinary Incontinence\tHIV Infections\t1\t1.6175293416348633\nUrinary Incontinence\tAcquired Immunodeficiency Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tAIDS Dementia Complex\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroschistosomiasis\t1\t1.6175293416348633\nUrinary Incontinence\tEchinococcosis\t2\t3.2350586832697266\nUrinary Incontinence\tOxyuriasis\t1\t1.6175293416348633\nUrinary Incontinence\tStrongyloidiasis\t1\t1.6175293416348633\nUrinary Incontinence\tSchistosomiasis\t2\t3.2350586832697266\nUrinary Incontinence\tSchistosomiasis mansoni\t2\t3.2350586832697266\nUrinary Incontinence\tToxoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tCysts\t11\t17.792822757983497\nUrinary Incontinence\tArachnoid Cysts\t3\t4.852588024904589\nUrinary Incontinence\tBone Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tDermoid Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tEpidermal Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tLymphocele\t1\t1.6175293416348633\nUrinary Incontinence\tOvarian Cysts\t2\t3.2350586832697266\nUrinary Incontinence\tHamartoma\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Lymphoid\t1\t1.6175293416348633\nUrinary Incontinence\tPrecursor Cell Lymphoblastic Leukemia-Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Myeloid, Acute\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia, Monocytic, Acute\t1\t1.6175293416348633\nUrinary Incontinence\tSarcoma, Myeloid\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHodgkin Disease\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Non-Hodgkin\t2\t3.2350586832697266\nUrinary Incontinence\tLymphoma, B-Cell\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, AIDS-Related\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Large B-Cell, Diffuse\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, Large-Cell, Immunoblastic\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Adenosquamous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinosarcoma\t1\t1.6175293416348633\nUrinary Incontinence\tAngiolipoma\t2\t3.2350586832697266\nUrinary Incontinence\tLipoma\t11\t17.792822757983497\nUrinary Incontinence\tGiant Cell Tumor of Bone\t1\t1.6175293416348633\nUrinary Incontinence\tFibroma\t1\t1.6175293416348633\nUrinary Incontinence\tFibromatosis, Aggressive\t1\t1.6175293416348633\nUrinary Incontinence\tBrenner Tumor\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Muscle Tissue\t1\t1.6175293416348633\nUrinary Incontinence\tLeiomyoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma, Embryonal\t1\t1.6175293416348633\nUrinary Incontinence\tChordoma\t2\t3.2350586832697266\nUrinary Incontinence\tGerminoma\t2\t3.2350586832697266\nUrinary Incontinence\tDysgerminoma\t1\t1.6175293416348633\nUrinary Incontinence\tCraniopharyngioma\t1\t1.6175293416348633\nUrinary Incontinence\tGlioma\t2\t3.2350586832697266\nUrinary Incontinence\tGlioblastoma\t3\t4.852588024904589\nUrinary Incontinence\tEpendymoma\t2\t3.2350586832697266\nUrinary Incontinence\tGanglioglioma\t1\t1.6175293416348633\nUrinary Incontinence\tOligodendroglioma\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroblastoma\t3\t4.852588024904589\nUrinary Incontinence\tNeuroendocrine Tumors\t1\t1.6175293416348633\nUrinary Incontinence\tMelanoma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurilemmoma\t5\t8.087646708174317\nUrinary Incontinence\tParaganglioma\t1\t1.6175293416348633\nUrinary Incontinence\tTeratoma\t2\t3.2350586832697266\nUrinary Incontinence\tChoriocarcinoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Islet Cell\t1\t1.6175293416348633\nUrinary Incontinence\tSyringoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Villous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma\t10\t16.175293416348634\nUrinary Incontinence\tAdenocarcinoma\t32\t51.760938932315625\nUrinary Incontinence\tAdenocarcinoma, Clear Cell\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Follicular\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Mucinous\t1\t1.6175293416348633\nUrinary Incontinence\tLinitis Plastica\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Ductal, Breast\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Lobular\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Signet Ring Cell\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Intraepithelial Neoplasia\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Small Cell\t2\t3.2350586832697266\nUrinary Incontinence\tCarcinoma, Squamous Cell\t5\t8.087646708174317\nUrinary Incontinence\tCarcinoma, Transitional Cell\t5\t8.087646708174317\nUrinary Incontinence\tMeningioma\t5\t8.087646708174317\nUrinary Incontinence\tNeurofibroma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatoses\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatosis 1\t3\t4.852588024904589\nUrinary Incontinence\tMultiple Myeloma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma\t2\t3.2350586832697266\nUrinary Incontinence\tHemangioendothelioma, Epithelioid\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioblastoma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma, Cavernous\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tPeritoneal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRetroperitoneal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tAnal Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBone Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSkull Base Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tBreast Neoplasms\t9\t14.55776407471377\nUrinary Incontinence\tIntestinal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColorectal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColonic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRectal Neoplasms\t10\t16.175293416348634\nUrinary Incontinence\tAnus Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tOvarian Neoplasms\t7\t11.322705391444043\nUrinary Incontinence\tPituitary Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tTesticular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tThyroid Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tNasopharyngeal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBrain Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tCerebral Ventricle Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tInfratentorial Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCerebellar Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tHypothalamic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCentral Nervous System Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tMeningeal Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tMeningeal Carcinomatosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Cord Neoplasms\t20\t32.35058683269727\nUrinary Incontinence\tEpidural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis, Transverse\t5\t8.087646708174317\nUrinary Incontinence\tParaneoplastic Cerebellar Degeneration\t1\t1.6175293416348633\nUrinary Incontinence\tParaneoplastic Polyneuropathy\t1\t1.6175293416348633\nUrinary Incontinence\tPeripheral Nervous System Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPelvic Neoplasms\t6\t9.705176049809179\nUrinary Incontinence\tSweat Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tVascular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tLung Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPleural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrogenital Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Female\t7\t11.322705391444043\nUrinary Incontinence\tFallopian Tube Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tUterine Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tEndometrial Neoplasms\t4\t6.470117366539453\nUrinary Incontinence\tUterine Cervical Neoplasms\t17\t27.497998807792676\nUrinary Incontinence\tVaginal Neoplasms\t12\t19.410352099618358\nUrinary Incontinence\tVulvar Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Male\t1\t1.6175293416348633\nUrinary Incontinence\tPenile Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Neoplasms\t224\t362.32657252620936\nUrinary Incontinence\tUrologic Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tUreteral Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrethral Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tUrinary Bladder Neoplasms\t31\t50.14340959068076\nUrinary Incontinence\tNeoplasms, Multiple Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Second Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasm Invasiveness\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Unknown Primary\t2\t3.2350586832697266\nUrinary Incontinence\tNeoplasm Recurrence, Local\t10\t16.175293416348634\nUrinary Incontinence\tParaneoplastic Syndromes\t2\t3.2350586832697266\nUrinary Incontinence\tPregnancy Complications, Neoplastic\t1\t1.6175293416348633\nUrinary Incontinence\tBone Diseases, Developmental\t2\t3.2350586832697266\nUrinary Incontinence\tAchondroplasia\t1\t1.6175293416348633\nUrinary Incontinence\tKlippel-Feil Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tRubinstein-Taybi Syndrome\t1\t1.6175293416348633\nUrinary Incontinence\tMarfan Syndrome\t4\t6.470117366539453\nUrinary Incontinence\tPlatybasia\t1\t1.6175293416348633\nUrinary Incontinence\tOsteoporosis\t6\t9.705176049809179\nUrinary Incontinence\tOsteoporosis, Postmenopausal\t2\t3.2350586832697266\nUrinary Incontinence\tOsteitis Deformans\t2\t3.2350586832697266\nUrinary Incontinence\tSpinal Diseases\t6\t9.705176049809179\nUrinary Incontinence\tIntervertebral Disk Displacement\t11\t17.792822757983497\nUrinary Incontinence\tSpinal Osteophytosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Stenosis\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis, Psoriatic\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolysis\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolisthesis\t1\t1.6175293416348633\nUrinary Incontinence\tClubfoot\t1\t1.6175293416348633\nUrinary Incontinence\tGranuloma, Giant Cell\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis\t3\t4.852588024904589\nUrinary Incontinence\tArthritis, Rheumatoid\t2\t3.2350586832697266\nUrinary Incontinence\tSjogrens Syndrome                  0.000000000
    ## Pasteurellosis, Pneumonic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      0.000000000
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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Meningomyelocele
    ## Pleural Neoplasms                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  0.002155779
    ## Muscular Disorders, Atrophic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       0.011929046
    ## Meningomyelocele                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   1.000000000
    ## Sjogrens Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGastroesophageal Reflux\t1\t3.543332367391082\nUrinary Bladder, Overactive\tColitis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIntestinal Pseudo-Obstruction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFecal Incontinence\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLiver Cirrhosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tXerostomia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Apnea Syndromes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCough\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Acute Disseminated\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple Sclerosis\t19\t67.32331498043055\nUrinary Bladder, Overactive\tMyasthenia Gravis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Autoimmune, Experimental\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAutonomic Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple System Atrophy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCentral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParkinson Disease\t8\t28.346658939128655\nUrinary Bladder, Overactive\tCerebral Palsy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Ischemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCerebral Infarction\t6\t21.25999420434649\nUrinary Bladder, Overactive\tInfarction, Middle Cerebral Artery\t2\t7.086664734782164\nUrinary Bladder, Overactive\tStroke\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDementia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tAlzheimer Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHydrocephalus, Normal Pressure\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHyperprolactinemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMovement Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEssential Tremor\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSpinal Cord Diseases\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSpinal Cord Injuries\t26\t92.12664155216812\nUrinary Bladder, Overactive\tMeningomyelocele\t4\t14.173329469564328\nUrinary Bladder, Overactive\tSpinal Dysraphism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAmyloid Neuropathies, Familial\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAtaxia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDelirium\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSyncope\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMemory Disorders\t4\t14.173329469564328\nUrinary Bladder, Overactive\tNeurogenic Inflammation\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMuscle Hypertonia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPain\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPain, Intractable\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParaplegia\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperesthesia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Neurogenic\t91\t322.44324543258847\nUrinary Bladder, Overactive\tPeripheral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetic Neuropathies\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Disorders, Intrinsic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tRestless Legs Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGlaucoma\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Hyperplasia\t49\t173.623286002163\nUrinary Bladder, Overactive\tProstatitis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSexual Dysfunction, Physiological\t10\t35.43332367391082\nUrinary Bladder, Overactive\tErectile Dysfunction\t8\t28.346658939128655\nUrinary Bladder, Overactive\tImpotence, Vasculogenic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrologic Diseases\t21\t74.40997971521271\nUrinary Bladder, Overactive\tUreteral Calculi\t2\t7.086664734782164\nUrinary Bladder, Overactive\tUrethral Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrethral Obstruction\t3\t10.629997102173245\nUrinary Bladder, Overactive\tUrinary Bladder Neck Obstruction\t41\t145.27662706303437\nUrinary Bladder, Overactive\tUrinary Bladder Diseases\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis, Interstitial\t27\t95.66997391955921\nUrinary Bladder, Overactive\tCystocele\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Overactive\t1194\t4230.738846664952\nUrinary Bladder, Overactive\tVesico-Ureteral Reflux\t7\t24.803326571737575\nUrinary Bladder, Overactive\tUrination Disorders\t42\t148.81995943042543\nUrinary Bladder, Overactive\tEnuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tNocturnal Enuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHematuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPolyuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Incontinence\t151\t535.0431874760534\nUrinary Bladder, Overactive\tUrinary Incontinence, Stress\t48\t170.07995363477193\nUrinary Bladder, Overactive\tUrinary Incontinence, Urge\t69\t244.48993334998465\nUrinary Bladder, Overactive\tUrinary Retention\t20\t70.86664734782164\nUrinary Bladder, Overactive\tFemale Urogenital Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFallopian Tube Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEndometriosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Prolapse\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPregnancy Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor, Premature\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPuerperal Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHeart Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLong QT Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tTorsades de Pointes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMyocardial Infarction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHypertension\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDrug Eruptions\t2\t7.086664734782164\nUrinary Bladder, Overactive\tLichenoid Eruptions\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHyperhidrosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCalcinosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus, Experimental\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Mellitus, Type 2\t2\t7.086664734782164\nUrinary Bladder, Overactive\tMetabolic Syndrome X\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperlipidemias\t2\t7.086664734782164\nUrinary Bladder, Overactive\tObesity\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Complications\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHypogonadism\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHypersensitivity\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCognition Disorders\t8\t28.346658939128655\nUrinary Bladder, Overactive\tSexual Dysfunctions, Psychological\t2\t7.086664734782164\nUrinary Bladder, Overactive\tTranssexualism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPelvic Organ Prolapse\t7\t24.803326571737575\nUrinary Bladder, Overactive\tGenetic Predisposition to Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCicatrix\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIschemia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tNerve Degeneration\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPostoperative Complications\t6\t21.25999420434649\nUrinary Incontinence\tBacterial Infections\t6\t9.705176049809179\nUrinary Incontinence\tBacteremia\t1\t1.6175293416348633\nUrinary Incontinence\tEpidural Abscess\t2\t3.2350586832697266\nUrinary Incontinence\tNeurosyphilis\t5\t8.087646708174317\nUrinary Incontinence\tFournier Gangrene\t1\t1.6175293416348633\nUrinary Incontinence\tLyme Disease\t2\t3.2350586832697266\nUrinary Incontinence\tMelioidosis\t1\t1.6175293416348633\nUrinary Incontinence\tChlamydia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEnterobacteriaceae Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEscherichia coli Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHelicobacter Infections\t1\t1.6175293416348633\nUrinary Incontinence\tPseudomonas Infections\t2\t3.2350586832697266\nUrinary Incontinence\tBoutonneuse Fever\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculoma\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Miliary\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Spinal\t2\t3.2350586832697266\nUrinary Incontinence\tTuberculosis, Urogenital\t3\t4.852588024904589\nUrinary Incontinence\tNocardia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStaphylococcal Infections\t2\t3.2350586832697266\nUrinary Incontinence\tStaphylococcal Skin Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStreptococcal Infections\t1\t1.6175293416348633\nUrinary Incontinence\tInfection\t1\t1.6175293416348633\nUrinary Incontinence\tOsteitis\t2\t3.2350586832697266\nUrinary Incontinence\tOsteomyelitis\t4\t6.470117366539453\nUrinary Incontinence\tSpondylitis\t1\t1.6175293416348633\nUrinary Incontinence\tCommunicable Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tCommunity-Acquired Infections\t1\t1.6175293416348633\nUrinary Incontinence\tCross Infection\t3\t4.852588024904589\nUrinary Incontinence\tAIDS-Related Opportunistic Infections\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Infection\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Inflammatory Disease\t1\t1.6175293416348633\nUrinary Incontinence\tPregnancy Complications, Infectious\t1\t1.6175293416348633\nUrinary Incontinence\tProsthesis-Related Infections\t5\t8.087646708174317\nUrinary Incontinence\tRespiratory Tract Infections\t2\t3.2350586832697266\nUrinary Incontinence\tSepsis\t1\t1.6175293416348633\nUrinary Incontinence\tSexually Transmitted Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tAbscess\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tLiver Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tUrinary Tract Infections\t118\t190.86846231291386\nUrinary Incontinence\tBacteriuria\t26\t42.05576288250644\nUrinary Incontinence\tPyuria\t2\t3.2350586832697266\nUrinary Incontinence\tWound Infection\t1\t1.6175293416348633\nUrinary Incontinence\tSurgical Wound Infection\t2\t3.2350586832697266\nUrinary Incontinence\tAspergillosis\t1\t1.6175293416348633\nUrinary Incontinence\tCandidiasis\t3\t4.852588024904589\nUrinary Incontinence\tMeningitis, Cryptococcal\t1\t1.6175293416348633\nUrinary Incontinence\tHistoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tWest Nile Fever\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Viral\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Herpes Simplex\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis\t5\t8.087646708174317\nUrinary Incontinence\tParaparesis, Tropical Spastic\t4\t6.470117366539453\nUrinary Incontinence\tChickenpox\t3\t4.852588024904589\nUrinary Incontinence\tCytomegalovirus Infections\t1\t1.6175293416348633\nUrinary Incontinence\tBurkitt Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Genitalis\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Zoster\t4\t6.470117366539453\nUrinary Incontinence\tCondylomata Acuminata\t1\t1.6175293416348633\nUrinary Incontinence\tDistemper\t1\t1.6175293416348633\nUrinary Incontinence\tMumps\t1\t1.6175293416348633\nUrinary Incontinence\tCommon Cold\t2\t3.2350586832697266\nUrinary Incontinence\tHTLV-I Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHTLV-II Infections\t2\t3.2350586832697266\nUrinary Incontinence\tHIV Infections\t1\t1.6175293416348633\nUrinary Incontinence\tAcquired Immunodeficiency Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tAIDS Dementia Complex\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroschistosomiasis\t1\t1.6175293416348633\nUrinary Incontinence\tEchinococcosis\t2\t3.2350586832697266\nUrinary Incontinence\tOxyuriasis\t1\t1.6175293416348633\nUrinary Incontinence\tStrongyloidiasis\t1\t1.6175293416348633\nUrinary Incontinence\tSchistosomiasis\t2\t3.2350586832697266\nUrinary Incontinence\tSchistosomiasis mansoni\t2\t3.2350586832697266\nUrinary Incontinence\tToxoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tCysts\t11\t17.792822757983497\nUrinary Incontinence\tArachnoid Cysts\t3\t4.852588024904589\nUrinary Incontinence\tBone Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tDermoid Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tEpidermal Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tLymphocele\t1\t1.6175293416348633\nUrinary Incontinence\tOvarian Cysts\t2\t3.2350586832697266\nUrinary Incontinence\tHamartoma\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Lymphoid\t1\t1.6175293416348633\nUrinary Incontinence\tPrecursor Cell Lymphoblastic Leukemia-Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Myeloid, Acute\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia, Monocytic, Acute\t1\t1.6175293416348633\nUrinary Incontinence\tSarcoma, Myeloid\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHodgkin Disease\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Non-Hodgkin\t2\t3.2350586832697266\nUrinary Incontinence\tLymphoma, B-Cell\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, AIDS-Related\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Large B-Cell, Diffuse\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, Large-Cell, Immunoblastic\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Adenosquamous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinosarcoma\t1\t1.6175293416348633\nUrinary Incontinence\tAngiolipoma\t2\t3.2350586832697266\nUrinary Incontinence\tLipoma\t11\t17.792822757983497\nUrinary Incontinence\tGiant Cell Tumor of Bone\t1\t1.6175293416348633\nUrinary Incontinence\tFibroma\t1\t1.6175293416348633\nUrinary Incontinence\tFibromatosis, Aggressive\t1\t1.6175293416348633\nUrinary Incontinence\tBrenner Tumor\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Muscle Tissue\t1\t1.6175293416348633\nUrinary Incontinence\tLeiomyoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma, Embryonal\t1\t1.6175293416348633\nUrinary Incontinence\tChordoma\t2\t3.2350586832697266\nUrinary Incontinence\tGerminoma\t2\t3.2350586832697266\nUrinary Incontinence\tDysgerminoma\t1\t1.6175293416348633\nUrinary Incontinence\tCraniopharyngioma\t1\t1.6175293416348633\nUrinary Incontinence\tGlioma\t2\t3.2350586832697266\nUrinary Incontinence\tGlioblastoma\t3\t4.852588024904589\nUrinary Incontinence\tEpendymoma\t2\t3.2350586832697266\nUrinary Incontinence\tGanglioglioma\t1\t1.6175293416348633\nUrinary Incontinence\tOligodendroglioma\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroblastoma\t3\t4.852588024904589\nUrinary Incontinence\tNeuroendocrine Tumors\t1\t1.6175293416348633\nUrinary Incontinence\tMelanoma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurilemmoma\t5\t8.087646708174317\nUrinary Incontinence\tParaganglioma\t1\t1.6175293416348633\nUrinary Incontinence\tTeratoma\t2\t3.2350586832697266\nUrinary Incontinence\tChoriocarcinoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Islet Cell\t1\t1.6175293416348633\nUrinary Incontinence\tSyringoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Villous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma\t10\t16.175293416348634\nUrinary Incontinence\tAdenocarcinoma\t32\t51.760938932315625\nUrinary Incontinence\tAdenocarcinoma, Clear Cell\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Follicular\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Mucinous\t1\t1.6175293416348633\nUrinary Incontinence\tLinitis Plastica\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Ductal, Breast\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Lobular\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Signet Ring Cell\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Intraepithelial Neoplasia\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Small Cell\t2\t3.2350586832697266\nUrinary Incontinence\tCarcinoma, Squamous Cell\t5\t8.087646708174317\nUrinary Incontinence\tCarcinoma, Transitional Cell\t5\t8.087646708174317\nUrinary Incontinence\tMeningioma\t5\t8.087646708174317\nUrinary Incontinence\tNeurofibroma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatoses\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatosis 1\t3\t4.852588024904589\nUrinary Incontinence\tMultiple Myeloma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma\t2\t3.2350586832697266\nUrinary Incontinence\tHemangioendothelioma, Epithelioid\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioblastoma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma, Cavernous\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tPeritoneal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRetroperitoneal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tAnal Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBone Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSkull Base Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tBreast Neoplasms\t9\t14.55776407471377\nUrinary Incontinence\tIntestinal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColorectal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColonic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRectal Neoplasms\t10\t16.175293416348634\nUrinary Incontinence\tAnus Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tOvarian Neoplasms\t7\t11.322705391444043\nUrinary Incontinence\tPituitary Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tTesticular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tThyroid Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tNasopharyngeal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBrain Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tCerebral Ventricle Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tInfratentorial Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCerebellar Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tHypothalamic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCentral Nervous System Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tMeningeal Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tMeningeal Carcinomatosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Cord Neoplasms\t20\t32.35058683269727\nUrinary Incontinence\tEpidural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis, Transverse\t5\t8.087646708174317\nUrinary Incontinence\tParaneoplastic Cerebellar Degeneration\t1\t1.6175293416348633\nUrinary Incontinence\tParaneoplastic Polyneuropathy\t1\t1.6175293416348633\nUrinary Incontinence\tPeripheral Nervous System Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPelvic Neoplasms\t6\t9.705176049809179\nUrinary Incontinence\tSweat Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tVascular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tLung Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPleural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrogenital Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Female\t7\t11.322705391444043\nUrinary Incontinence\tFallopian Tube Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tUterine Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tEndometrial Neoplasms\t4\t6.470117366539453\nUrinary Incontinence\tUterine Cervical Neoplasms\t17\t27.497998807792676\nUrinary Incontinence\tVaginal Neoplasms\t12\t19.410352099618358\nUrinary Incontinence\tVulvar Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Male\t1\t1.6175293416348633\nUrinary Incontinence\tPenile Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Neoplasms\t224\t362.32657252620936\nUrinary Incontinence\tUrologic Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tUreteral Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrethral Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tUrinary Bladder Neoplasms\t31\t50.14340959068076\nUrinary Incontinence\tNeoplasms, Multiple Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Second Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasm Invasiveness\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Unknown Primary\t2\t3.2350586832697266\nUrinary Incontinence\tNeoplasm Recurrence, Local\t10\t16.175293416348634\nUrinary Incontinence\tParaneoplastic Syndromes\t2\t3.2350586832697266\nUrinary Incontinence\tPregnancy Complications, Neoplastic\t1\t1.6175293416348633\nUrinary Incontinence\tBone Diseases, Developmental\t2\t3.2350586832697266\nUrinary Incontinence\tAchondroplasia\t1\t1.6175293416348633\nUrinary Incontinence\tKlippel-Feil Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tRubinstein-Taybi Syndrome\t1\t1.6175293416348633\nUrinary Incontinence\tMarfan Syndrome\t4\t6.470117366539453\nUrinary Incontinence\tPlatybasia\t1\t1.6175293416348633\nUrinary Incontinence\tOsteoporosis\t6\t9.705176049809179\nUrinary Incontinence\tOsteoporosis, Postmenopausal\t2\t3.2350586832697266\nUrinary Incontinence\tOsteitis Deformans\t2\t3.2350586832697266\nUrinary Incontinence\tSpinal Diseases\t6\t9.705176049809179\nUrinary Incontinence\tIntervertebral Disk Displacement\t11\t17.792822757983497\nUrinary Incontinence\tSpinal Osteophytosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Stenosis\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis, Psoriatic\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolysis\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolisthesis\t1\t1.6175293416348633\nUrinary Incontinence\tClubfoot\t1\t1.6175293416348633\nUrinary Incontinence\tGranuloma, Giant Cell\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis\t3\t4.852588024904589\nUrinary Incontinence\tArthritis, Rheumatoid\t2\t3.2350586832697266\nUrinary Incontinence\tSjogrens Syndrome      0.000000000
    ## Pasteurellosis, Pneumonic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          0.000000000
    ##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Sjogrens Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGastroesophageal Reflux\t1\t3.543332367391082\nUrinary Bladder, Overactive\tColitis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIntestinal Pseudo-Obstruction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFecal Incontinence\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLiver Cirrhosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tXerostomia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Apnea Syndromes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCough\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Acute Disseminated\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple Sclerosis\t19\t67.32331498043055\nUrinary Bladder, Overactive\tMyasthenia Gravis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Autoimmune, Experimental\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAutonomic Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple System Atrophy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCentral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParkinson Disease\t8\t28.346658939128655\nUrinary Bladder, Overactive\tCerebral Palsy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Ischemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCerebral Infarction\t6\t21.25999420434649\nUrinary Bladder, Overactive\tInfarction, Middle Cerebral Artery\t2\t7.086664734782164\nUrinary Bladder, Overactive\tStroke\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDementia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tAlzheimer Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHydrocephalus, Normal Pressure\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHyperprolactinemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMovement Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEssential Tremor\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSpinal Cord Diseases\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSpinal Cord Injuries\t26\t92.12664155216812\nUrinary Bladder, Overactive\tMeningomyelocele\t4\t14.173329469564328\nUrinary Bladder, Overactive\tSpinal Dysraphism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAmyloid Neuropathies, Familial\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAtaxia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDelirium\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSyncope\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMemory Disorders\t4\t14.173329469564328\nUrinary Bladder, Overactive\tNeurogenic Inflammation\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMuscle Hypertonia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPain\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPain, Intractable\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParaplegia\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperesthesia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Neurogenic\t91\t322.44324543258847\nUrinary Bladder, Overactive\tPeripheral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetic Neuropathies\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Disorders, Intrinsic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tRestless Legs Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGlaucoma\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Hyperplasia\t49\t173.623286002163\nUrinary Bladder, Overactive\tProstatitis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSexual Dysfunction, Physiological\t10\t35.43332367391082\nUrinary Bladder, Overactive\tErectile Dysfunction\t8\t28.346658939128655\nUrinary Bladder, Overactive\tImpotence, Vasculogenic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrologic Diseases\t21\t74.40997971521271\nUrinary Bladder, Overactive\tUreteral Calculi\t2\t7.086664734782164\nUrinary Bladder, Overactive\tUrethral Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrethral Obstruction\t3\t10.629997102173245\nUrinary Bladder, Overactive\tUrinary Bladder Neck Obstruction\t41\t145.27662706303437\nUrinary Bladder, Overactive\tUrinary Bladder Diseases\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis, Interstitial\t27\t95.66997391955921\nUrinary Bladder, Overactive\tCystocele\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Overactive\t1194\t4230.738846664952\nUrinary Bladder, Overactive\tVesico-Ureteral Reflux\t7\t24.803326571737575\nUrinary Bladder, Overactive\tUrination Disorders\t42\t148.81995943042543\nUrinary Bladder, Overactive\tEnuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tNocturnal Enuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHematuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPolyuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Incontinence\t151\t535.0431874760534\nUrinary Bladder, Overactive\tUrinary Incontinence, Stress\t48\t170.07995363477193\nUrinary Bladder, Overactive\tUrinary Incontinence, Urge\t69\t244.48993334998465\nUrinary Bladder, Overactive\tUrinary Retention\t20\t70.86664734782164\nUrinary Bladder, Overactive\tFemale Urogenital Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFallopian Tube Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEndometriosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Prolapse\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPregnancy Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor, Premature\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPuerperal Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHeart Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLong QT Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tTorsades de Pointes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMyocardial Infarction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHypertension\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDrug Eruptions\t2\t7.086664734782164\nUrinary Bladder, Overactive\tLichenoid Eruptions\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHyperhidrosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCalcinosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus, Experimental\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Mellitus, Type 2\t2\t7.086664734782164\nUrinary Bladder, Overactive\tMetabolic Syndrome X\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperlipidemias\t2\t7.086664734782164\nUrinary Bladder, Overactive\tObesity\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Complications\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHypogonadism\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHypersensitivity\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCognition Disorders\t8\t28.346658939128655\nUrinary Bladder, Overactive\tSexual Dysfunctions, Psychological\t2\t7.086664734782164\nUrinary Bladder, Overactive\tTranssexualism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPelvic Organ Prolapse\t7\t24.803326571737575\nUrinary Bladder, Overactive\tGenetic Predisposition to Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCicatrix\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIschemia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tNerve Degeneration\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPostoperative Complications\t6\t21.25999420434649\nUrinary Incontinence\tBacterial Infections\t6\t9.705176049809179\nUrinary Incontinence\tBacteremia\t1\t1.6175293416348633\nUrinary Incontinence\tEpidural Abscess\t2\t3.2350586832697266\nUrinary Incontinence\tNeurosyphilis\t5\t8.087646708174317\nUrinary Incontinence\tFournier Gangrene\t1\t1.6175293416348633\nUrinary Incontinence\tLyme Disease\t2\t3.2350586832697266\nUrinary Incontinence\tMelioidosis\t1\t1.6175293416348633\nUrinary Incontinence\tChlamydia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEnterobacteriaceae Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEscherichia coli Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHelicobacter Infections\t1\t1.6175293416348633\nUrinary Incontinence\tPseudomonas Infections\t2\t3.2350586832697266\nUrinary Incontinence\tBoutonneuse Fever\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculoma\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Miliary\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Spinal\t2\t3.2350586832697266\nUrinary Incontinence\tTuberculosis, Urogenital\t3\t4.852588024904589\nUrinary Incontinence\tNocardia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStaphylococcal Infections\t2\t3.2350586832697266\nUrinary Incontinence\tStaphylococcal Skin Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStreptococcal Infections\t1\t1.6175293416348633\nUrinary Incontinence\tInfection\t1\t1.6175293416348633\nUrinary Incontinence\tOsteitis\t2\t3.2350586832697266\nUrinary Incontinence\tOsteomyelitis\t4\t6.470117366539453\nUrinary Incontinence\tSpondylitis\t1\t1.6175293416348633\nUrinary Incontinence\tCommunicable Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tCommunity-Acquired Infections\t1\t1.6175293416348633\nUrinary Incontinence\tCross Infection\t3\t4.852588024904589\nUrinary Incontinence\tAIDS-Related Opportunistic Infections\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Infection\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Inflammatory Disease\t1\t1.6175293416348633\nUrinary Incontinence\tPregnancy Complications, Infectious\t1\t1.6175293416348633\nUrinary Incontinence\tProsthesis-Related Infections\t5\t8.087646708174317\nUrinary Incontinence\tRespiratory Tract Infections\t2\t3.2350586832697266\nUrinary Incontinence\tSepsis\t1\t1.6175293416348633\nUrinary Incontinence\tSexually Transmitted Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tAbscess\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tLiver Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tUrinary Tract Infections\t118\t190.86846231291386\nUrinary Incontinence\tBacteriuria\t26\t42.05576288250644\nUrinary Incontinence\tPyuria\t2\t3.2350586832697266\nUrinary Incontinence\tWound Infection\t1\t1.6175293416348633\nUrinary Incontinence\tSurgical Wound Infection\t2\t3.2350586832697266\nUrinary Incontinence\tAspergillosis\t1\t1.6175293416348633\nUrinary Incontinence\tCandidiasis\t3\t4.852588024904589\nUrinary Incontinence\tMeningitis, Cryptococcal\t1\t1.6175293416348633\nUrinary Incontinence\tHistoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tWest Nile Fever\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Viral\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Herpes Simplex\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis\t5\t8.087646708174317\nUrinary Incontinence\tParaparesis, Tropical Spastic\t4\t6.470117366539453\nUrinary Incontinence\tChickenpox\t3\t4.852588024904589\nUrinary Incontinence\tCytomegalovirus Infections\t1\t1.6175293416348633\nUrinary Incontinence\tBurkitt Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Genitalis\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Zoster\t4\t6.470117366539453\nUrinary Incontinence\tCondylomata Acuminata\t1\t1.6175293416348633\nUrinary Incontinence\tDistemper\t1\t1.6175293416348633\nUrinary Incontinence\tMumps\t1\t1.6175293416348633\nUrinary Incontinence\tCommon Cold\t2\t3.2350586832697266\nUrinary Incontinence\tHTLV-I Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHTLV-II Infections\t2\t3.2350586832697266\nUrinary Incontinence\tHIV Infections\t1\t1.6175293416348633\nUrinary Incontinence\tAcquired Immunodeficiency Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tAIDS Dementia Complex\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroschistosomiasis\t1\t1.6175293416348633\nUrinary Incontinence\tEchinococcosis\t2\t3.2350586832697266\nUrinary Incontinence\tOxyuriasis\t1\t1.6175293416348633\nUrinary Incontinence\tStrongyloidiasis\t1\t1.6175293416348633\nUrinary Incontinence\tSchistosomiasis\t2\t3.2350586832697266\nUrinary Incontinence\tSchistosomiasis mansoni\t2\t3.2350586832697266\nUrinary Incontinence\tToxoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tCysts\t11\t17.792822757983497\nUrinary Incontinence\tArachnoid Cysts\t3\t4.852588024904589\nUrinary Incontinence\tBone Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tDermoid Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tEpidermal Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tLymphocele\t1\t1.6175293416348633\nUrinary Incontinence\tOvarian Cysts\t2\t3.2350586832697266\nUrinary Incontinence\tHamartoma\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Lymphoid\t1\t1.6175293416348633\nUrinary Incontinence\tPrecursor Cell Lymphoblastic Leukemia-Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Myeloid, Acute\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia, Monocytic, Acute\t1\t1.6175293416348633\nUrinary Incontinence\tSarcoma, Myeloid\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHodgkin Disease\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Non-Hodgkin\t2\t3.2350586832697266\nUrinary Incontinence\tLymphoma, B-Cell\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, AIDS-Related\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Large B-Cell, Diffuse\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, Large-Cell, Immunoblastic\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Adenosquamous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinosarcoma\t1\t1.6175293416348633\nUrinary Incontinence\tAngiolipoma\t2\t3.2350586832697266\nUrinary Incontinence\tLipoma\t11\t17.792822757983497\nUrinary Incontinence\tGiant Cell Tumor of Bone\t1\t1.6175293416348633\nUrinary Incontinence\tFibroma\t1\t1.6175293416348633\nUrinary Incontinence\tFibromatosis, Aggressive\t1\t1.6175293416348633\nUrinary Incontinence\tBrenner Tumor\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Muscle Tissue\t1\t1.6175293416348633\nUrinary Incontinence\tLeiomyoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma, Embryonal\t1\t1.6175293416348633\nUrinary Incontinence\tChordoma\t2\t3.2350586832697266\nUrinary Incontinence\tGerminoma\t2\t3.2350586832697266\nUrinary Incontinence\tDysgerminoma\t1\t1.6175293416348633\nUrinary Incontinence\tCraniopharyngioma\t1\t1.6175293416348633\nUrinary Incontinence\tGlioma\t2\t3.2350586832697266\nUrinary Incontinence\tGlioblastoma\t3\t4.852588024904589\nUrinary Incontinence\tEpendymoma\t2\t3.2350586832697266\nUrinary Incontinence\tGanglioglioma\t1\t1.6175293416348633\nUrinary Incontinence\tOligodendroglioma\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroblastoma\t3\t4.852588024904589\nUrinary Incontinence\tNeuroendocrine Tumors\t1\t1.6175293416348633\nUrinary Incontinence\tMelanoma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurilemmoma\t5\t8.087646708174317\nUrinary Incontinence\tParaganglioma\t1\t1.6175293416348633\nUrinary Incontinence\tTeratoma\t2\t3.2350586832697266\nUrinary Incontinence\tChoriocarcinoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Islet Cell\t1\t1.6175293416348633\nUrinary Incontinence\tSyringoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Villous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma\t10\t16.175293416348634\nUrinary Incontinence\tAdenocarcinoma\t32\t51.760938932315625\nUrinary Incontinence\tAdenocarcinoma, Clear Cell\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Follicular\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Mucinous\t1\t1.6175293416348633\nUrinary Incontinence\tLinitis Plastica\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Ductal, Breast\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Lobular\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Signet Ring Cell\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Intraepithelial Neoplasia\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Small Cell\t2\t3.2350586832697266\nUrinary Incontinence\tCarcinoma, Squamous Cell\t5\t8.087646708174317\nUrinary Incontinence\tCarcinoma, Transitional Cell\t5\t8.087646708174317\nUrinary Incontinence\tMeningioma\t5\t8.087646708174317\nUrinary Incontinence\tNeurofibroma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatoses\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatosis 1\t3\t4.852588024904589\nUrinary Incontinence\tMultiple Myeloma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma\t2\t3.2350586832697266\nUrinary Incontinence\tHemangioendothelioma, Epithelioid\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioblastoma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma, Cavernous\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tPeritoneal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRetroperitoneal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tAnal Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBone Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSkull Base Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tBreast Neoplasms\t9\t14.55776407471377\nUrinary Incontinence\tIntestinal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColorectal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColonic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRectal Neoplasms\t10\t16.175293416348634\nUrinary Incontinence\tAnus Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tOvarian Neoplasms\t7\t11.322705391444043\nUrinary Incontinence\tPituitary Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tTesticular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tThyroid Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tNasopharyngeal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBrain Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tCerebral Ventricle Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tInfratentorial Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCerebellar Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tHypothalamic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCentral Nervous System Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tMeningeal Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tMeningeal Carcinomatosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Cord Neoplasms\t20\t32.35058683269727\nUrinary Incontinence\tEpidural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis, Transverse\t5\t8.087646708174317\nUrinary Incontinence\tParaneoplastic Cerebellar Degeneration\t1\t1.6175293416348633\nUrinary Incontinence\tParaneoplastic Polyneuropathy\t1\t1.6175293416348633\nUrinary Incontinence\tPeripheral Nervous System Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPelvic Neoplasms\t6\t9.705176049809179\nUrinary Incontinence\tSweat Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tVascular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tLung Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPleural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrogenital Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Female\t7\t11.322705391444043\nUrinary Incontinence\tFallopian Tube Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tUterine Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tEndometrial Neoplasms\t4\t6.470117366539453\nUrinary Incontinence\tUterine Cervical Neoplasms\t17\t27.497998807792676\nUrinary Incontinence\tVaginal Neoplasms\t12\t19.410352099618358\nUrinary Incontinence\tVulvar Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Male\t1\t1.6175293416348633\nUrinary Incontinence\tPenile Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Neoplasms\t224\t362.32657252620936\nUrinary Incontinence\tUrologic Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tUreteral Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrethral Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tUrinary Bladder Neoplasms\t31\t50.14340959068076\nUrinary Incontinence\tNeoplasms, Multiple Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Second Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasm Invasiveness\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Unknown Primary\t2\t3.2350586832697266\nUrinary Incontinence\tNeoplasm Recurrence, Local\t10\t16.175293416348634\nUrinary Incontinence\tParaneoplastic Syndromes\t2\t3.2350586832697266\nUrinary Incontinence\tPregnancy Complications, Neoplastic\t1\t1.6175293416348633\nUrinary Incontinence\tBone Diseases, Developmental\t2\t3.2350586832697266\nUrinary Incontinence\tAchondroplasia\t1\t1.6175293416348633\nUrinary Incontinence\tKlippel-Feil Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tRubinstein-Taybi Syndrome\t1\t1.6175293416348633\nUrinary Incontinence\tMarfan Syndrome\t4\t6.470117366539453\nUrinary Incontinence\tPlatybasia\t1\t1.6175293416348633\nUrinary Incontinence\tOsteoporosis\t6\t9.705176049809179\nUrinary Incontinence\tOsteoporosis, Postmenopausal\t2\t3.2350586832697266\nUrinary Incontinence\tOsteitis Deformans\t2\t3.2350586832697266\nUrinary Incontinence\tSpinal Diseases\t6\t9.705176049809179\nUrinary Incontinence\tIntervertebral Disk Displacement\t11\t17.792822757983497\nUrinary Incontinence\tSpinal Osteophytosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Stenosis\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis, Psoriatic\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolysis\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolisthesis\t1\t1.6175293416348633\nUrinary Incontinence\tClubfoot\t1\t1.6175293416348633\nUrinary Incontinence\tGranuloma, Giant Cell\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis\t3\t4.852588024904589\nUrinary Incontinence\tArthritis, Rheumatoid\t2\t3.2350586832697266\nUrinary Incontinence\tSjogrens Syndrome
    ## Pleural Neoplasms                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  0
    ## Muscular Disorders, Atrophic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       0
    ## Meningomyelocele                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   0
    ## Sjogrens Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGastroesophageal Reflux\t1\t3.543332367391082\nUrinary Bladder, Overactive\tColitis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIntestinal Pseudo-Obstruction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFecal Incontinence\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLiver Cirrhosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tXerostomia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Apnea Syndromes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCough\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Acute Disseminated\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple Sclerosis\t19\t67.32331498043055\nUrinary Bladder, Overactive\tMyasthenia Gravis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Autoimmune, Experimental\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAutonomic Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple System Atrophy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCentral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParkinson Disease\t8\t28.346658939128655\nUrinary Bladder, Overactive\tCerebral Palsy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Ischemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCerebral Infarction\t6\t21.25999420434649\nUrinary Bladder, Overactive\tInfarction, Middle Cerebral Artery\t2\t7.086664734782164\nUrinary Bladder, Overactive\tStroke\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDementia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tAlzheimer Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHydrocephalus, Normal Pressure\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHyperprolactinemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMovement Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEssential Tremor\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSpinal Cord Diseases\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSpinal Cord Injuries\t26\t92.12664155216812\nUrinary Bladder, Overactive\tMeningomyelocele\t4\t14.173329469564328\nUrinary Bladder, Overactive\tSpinal Dysraphism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAmyloid Neuropathies, Familial\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAtaxia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDelirium\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSyncope\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMemory Disorders\t4\t14.173329469564328\nUrinary Bladder, Overactive\tNeurogenic Inflammation\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMuscle Hypertonia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPain\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPain, Intractable\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParaplegia\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperesthesia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Neurogenic\t91\t322.44324543258847\nUrinary Bladder, Overactive\tPeripheral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetic Neuropathies\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Disorders, Intrinsic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tRestless Legs Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGlaucoma\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Hyperplasia\t49\t173.623286002163\nUrinary Bladder, Overactive\tProstatitis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSexual Dysfunction, Physiological\t10\t35.43332367391082\nUrinary Bladder, Overactive\tErectile Dysfunction\t8\t28.346658939128655\nUrinary Bladder, Overactive\tImpotence, Vasculogenic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrologic Diseases\t21\t74.40997971521271\nUrinary Bladder, Overactive\tUreteral Calculi\t2\t7.086664734782164\nUrinary Bladder, Overactive\tUrethral Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrethral Obstruction\t3\t10.629997102173245\nUrinary Bladder, Overactive\tUrinary Bladder Neck Obstruction\t41\t145.27662706303437\nUrinary Bladder, Overactive\tUrinary Bladder Diseases\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis, Interstitial\t27\t95.66997391955921\nUrinary Bladder, Overactive\tCystocele\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Overactive\t1194\t4230.738846664952\nUrinary Bladder, Overactive\tVesico-Ureteral Reflux\t7\t24.803326571737575\nUrinary Bladder, Overactive\tUrination Disorders\t42\t148.81995943042543\nUrinary Bladder, Overactive\tEnuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tNocturnal Enuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHematuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPolyuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Incontinence\t151\t535.0431874760534\nUrinary Bladder, Overactive\tUrinary Incontinence, Stress\t48\t170.07995363477193\nUrinary Bladder, Overactive\tUrinary Incontinence, Urge\t69\t244.48993334998465\nUrinary Bladder, Overactive\tUrinary Retention\t20\t70.86664734782164\nUrinary Bladder, Overactive\tFemale Urogenital Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFallopian Tube Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEndometriosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Prolapse\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPregnancy Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor, Premature\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPuerperal Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHeart Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLong QT Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tTorsades de Pointes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMyocardial Infarction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHypertension\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDrug Eruptions\t2\t7.086664734782164\nUrinary Bladder, Overactive\tLichenoid Eruptions\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHyperhidrosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCalcinosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus, Experimental\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Mellitus, Type 2\t2\t7.086664734782164\nUrinary Bladder, Overactive\tMetabolic Syndrome X\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperlipidemias\t2\t7.086664734782164\nUrinary Bladder, Overactive\tObesity\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Complications\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHypogonadism\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHypersensitivity\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCognition Disorders\t8\t28.346658939128655\nUrinary Bladder, Overactive\tSexual Dysfunctions, Psychological\t2\t7.086664734782164\nUrinary Bladder, Overactive\tTranssexualism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPelvic Organ Prolapse\t7\t24.803326571737575\nUrinary Bladder, Overactive\tGenetic Predisposition to Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCicatrix\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIschemia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tNerve Degeneration\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPostoperative Complications\t6\t21.25999420434649\nUrinary Incontinence\tBacterial Infections\t6\t9.705176049809179\nUrinary Incontinence\tBacteremia\t1\t1.6175293416348633\nUrinary Incontinence\tEpidural Abscess\t2\t3.2350586832697266\nUrinary Incontinence\tNeurosyphilis\t5\t8.087646708174317\nUrinary Incontinence\tFournier Gangrene\t1\t1.6175293416348633\nUrinary Incontinence\tLyme Disease\t2\t3.2350586832697266\nUrinary Incontinence\tMelioidosis\t1\t1.6175293416348633\nUrinary Incontinence\tChlamydia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEnterobacteriaceae Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEscherichia coli Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHelicobacter Infections\t1\t1.6175293416348633\nUrinary Incontinence\tPseudomonas Infections\t2\t3.2350586832697266\nUrinary Incontinence\tBoutonneuse Fever\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculoma\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Miliary\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Spinal\t2\t3.2350586832697266\nUrinary Incontinence\tTuberculosis, Urogenital\t3\t4.852588024904589\nUrinary Incontinence\tNocardia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStaphylococcal Infections\t2\t3.2350586832697266\nUrinary Incontinence\tStaphylococcal Skin Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStreptococcal Infections\t1\t1.6175293416348633\nUrinary Incontinence\tInfection\t1\t1.6175293416348633\nUrinary Incontinence\tOsteitis\t2\t3.2350586832697266\nUrinary Incontinence\tOsteomyelitis\t4\t6.470117366539453\nUrinary Incontinence\tSpondylitis\t1\t1.6175293416348633\nUrinary Incontinence\tCommunicable Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tCommunity-Acquired Infections\t1\t1.6175293416348633\nUrinary Incontinence\tCross Infection\t3\t4.852588024904589\nUrinary Incontinence\tAIDS-Related Opportunistic Infections\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Infection\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Inflammatory Disease\t1\t1.6175293416348633\nUrinary Incontinence\tPregnancy Complications, Infectious\t1\t1.6175293416348633\nUrinary Incontinence\tProsthesis-Related Infections\t5\t8.087646708174317\nUrinary Incontinence\tRespiratory Tract Infections\t2\t3.2350586832697266\nUrinary Incontinence\tSepsis\t1\t1.6175293416348633\nUrinary Incontinence\tSexually Transmitted Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tAbscess\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tLiver Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tUrinary Tract Infections\t118\t190.86846231291386\nUrinary Incontinence\tBacteriuria\t26\t42.05576288250644\nUrinary Incontinence\tPyuria\t2\t3.2350586832697266\nUrinary Incontinence\tWound Infection\t1\t1.6175293416348633\nUrinary Incontinence\tSurgical Wound Infection\t2\t3.2350586832697266\nUrinary Incontinence\tAspergillosis\t1\t1.6175293416348633\nUrinary Incontinence\tCandidiasis\t3\t4.852588024904589\nUrinary Incontinence\tMeningitis, Cryptococcal\t1\t1.6175293416348633\nUrinary Incontinence\tHistoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tWest Nile Fever\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Viral\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Herpes Simplex\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis\t5\t8.087646708174317\nUrinary Incontinence\tParaparesis, Tropical Spastic\t4\t6.470117366539453\nUrinary Incontinence\tChickenpox\t3\t4.852588024904589\nUrinary Incontinence\tCytomegalovirus Infections\t1\t1.6175293416348633\nUrinary Incontinence\tBurkitt Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Genitalis\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Zoster\t4\t6.470117366539453\nUrinary Incontinence\tCondylomata Acuminata\t1\t1.6175293416348633\nUrinary Incontinence\tDistemper\t1\t1.6175293416348633\nUrinary Incontinence\tMumps\t1\t1.6175293416348633\nUrinary Incontinence\tCommon Cold\t2\t3.2350586832697266\nUrinary Incontinence\tHTLV-I Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHTLV-II Infections\t2\t3.2350586832697266\nUrinary Incontinence\tHIV Infections\t1\t1.6175293416348633\nUrinary Incontinence\tAcquired Immunodeficiency Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tAIDS Dementia Complex\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroschistosomiasis\t1\t1.6175293416348633\nUrinary Incontinence\tEchinococcosis\t2\t3.2350586832697266\nUrinary Incontinence\tOxyuriasis\t1\t1.6175293416348633\nUrinary Incontinence\tStrongyloidiasis\t1\t1.6175293416348633\nUrinary Incontinence\tSchistosomiasis\t2\t3.2350586832697266\nUrinary Incontinence\tSchistosomiasis mansoni\t2\t3.2350586832697266\nUrinary Incontinence\tToxoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tCysts\t11\t17.792822757983497\nUrinary Incontinence\tArachnoid Cysts\t3\t4.852588024904589\nUrinary Incontinence\tBone Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tDermoid Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tEpidermal Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tLymphocele\t1\t1.6175293416348633\nUrinary Incontinence\tOvarian Cysts\t2\t3.2350586832697266\nUrinary Incontinence\tHamartoma\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Lymphoid\t1\t1.6175293416348633\nUrinary Incontinence\tPrecursor Cell Lymphoblastic Leukemia-Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Myeloid, Acute\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia, Monocytic, Acute\t1\t1.6175293416348633\nUrinary Incontinence\tSarcoma, Myeloid\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHodgkin Disease\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Non-Hodgkin\t2\t3.2350586832697266\nUrinary Incontinence\tLymphoma, B-Cell\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, AIDS-Related\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Large B-Cell, Diffuse\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, Large-Cell, Immunoblastic\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Adenosquamous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinosarcoma\t1\t1.6175293416348633\nUrinary Incontinence\tAngiolipoma\t2\t3.2350586832697266\nUrinary Incontinence\tLipoma\t11\t17.792822757983497\nUrinary Incontinence\tGiant Cell Tumor of Bone\t1\t1.6175293416348633\nUrinary Incontinence\tFibroma\t1\t1.6175293416348633\nUrinary Incontinence\tFibromatosis, Aggressive\t1\t1.6175293416348633\nUrinary Incontinence\tBrenner Tumor\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Muscle Tissue\t1\t1.6175293416348633\nUrinary Incontinence\tLeiomyoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma, Embryonal\t1\t1.6175293416348633\nUrinary Incontinence\tChordoma\t2\t3.2350586832697266\nUrinary Incontinence\tGerminoma\t2\t3.2350586832697266\nUrinary Incontinence\tDysgerminoma\t1\t1.6175293416348633\nUrinary Incontinence\tCraniopharyngioma\t1\t1.6175293416348633\nUrinary Incontinence\tGlioma\t2\t3.2350586832697266\nUrinary Incontinence\tGlioblastoma\t3\t4.852588024904589\nUrinary Incontinence\tEpendymoma\t2\t3.2350586832697266\nUrinary Incontinence\tGanglioglioma\t1\t1.6175293416348633\nUrinary Incontinence\tOligodendroglioma\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroblastoma\t3\t4.852588024904589\nUrinary Incontinence\tNeuroendocrine Tumors\t1\t1.6175293416348633\nUrinary Incontinence\tMelanoma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurilemmoma\t5\t8.087646708174317\nUrinary Incontinence\tParaganglioma\t1\t1.6175293416348633\nUrinary Incontinence\tTeratoma\t2\t3.2350586832697266\nUrinary Incontinence\tChoriocarcinoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Islet Cell\t1\t1.6175293416348633\nUrinary Incontinence\tSyringoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Villous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma\t10\t16.175293416348634\nUrinary Incontinence\tAdenocarcinoma\t32\t51.760938932315625\nUrinary Incontinence\tAdenocarcinoma, Clear Cell\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Follicular\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Mucinous\t1\t1.6175293416348633\nUrinary Incontinence\tLinitis Plastica\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Ductal, Breast\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Lobular\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Signet Ring Cell\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Intraepithelial Neoplasia\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Small Cell\t2\t3.2350586832697266\nUrinary Incontinence\tCarcinoma, Squamous Cell\t5\t8.087646708174317\nUrinary Incontinence\tCarcinoma, Transitional Cell\t5\t8.087646708174317\nUrinary Incontinence\tMeningioma\t5\t8.087646708174317\nUrinary Incontinence\tNeurofibroma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatoses\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatosis 1\t3\t4.852588024904589\nUrinary Incontinence\tMultiple Myeloma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma\t2\t3.2350586832697266\nUrinary Incontinence\tHemangioendothelioma, Epithelioid\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioblastoma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma, Cavernous\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tPeritoneal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRetroperitoneal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tAnal Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBone Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSkull Base Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tBreast Neoplasms\t9\t14.55776407471377\nUrinary Incontinence\tIntestinal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColorectal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColonic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRectal Neoplasms\t10\t16.175293416348634\nUrinary Incontinence\tAnus Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tOvarian Neoplasms\t7\t11.322705391444043\nUrinary Incontinence\tPituitary Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tTesticular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tThyroid Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tNasopharyngeal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBrain Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tCerebral Ventricle Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tInfratentorial Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCerebellar Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tHypothalamic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCentral Nervous System Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tMeningeal Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tMeningeal Carcinomatosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Cord Neoplasms\t20\t32.35058683269727\nUrinary Incontinence\tEpidural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis, Transverse\t5\t8.087646708174317\nUrinary Incontinence\tParaneoplastic Cerebellar Degeneration\t1\t1.6175293416348633\nUrinary Incontinence\tParaneoplastic Polyneuropathy\t1\t1.6175293416348633\nUrinary Incontinence\tPeripheral Nervous System Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPelvic Neoplasms\t6\t9.705176049809179\nUrinary Incontinence\tSweat Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tVascular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tLung Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPleural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrogenital Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Female\t7\t11.322705391444043\nUrinary Incontinence\tFallopian Tube Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tUterine Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tEndometrial Neoplasms\t4\t6.470117366539453\nUrinary Incontinence\tUterine Cervical Neoplasms\t17\t27.497998807792676\nUrinary Incontinence\tVaginal Neoplasms\t12\t19.410352099618358\nUrinary Incontinence\tVulvar Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Male\t1\t1.6175293416348633\nUrinary Incontinence\tPenile Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Neoplasms\t224\t362.32657252620936\nUrinary Incontinence\tUrologic Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tUreteral Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrethral Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tUrinary Bladder Neoplasms\t31\t50.14340959068076\nUrinary Incontinence\tNeoplasms, Multiple Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Second Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasm Invasiveness\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Unknown Primary\t2\t3.2350586832697266\nUrinary Incontinence\tNeoplasm Recurrence, Local\t10\t16.175293416348634\nUrinary Incontinence\tParaneoplastic Syndromes\t2\t3.2350586832697266\nUrinary Incontinence\tPregnancy Complications, Neoplastic\t1\t1.6175293416348633\nUrinary Incontinence\tBone Diseases, Developmental\t2\t3.2350586832697266\nUrinary Incontinence\tAchondroplasia\t1\t1.6175293416348633\nUrinary Incontinence\tKlippel-Feil Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tRubinstein-Taybi Syndrome\t1\t1.6175293416348633\nUrinary Incontinence\tMarfan Syndrome\t4\t6.470117366539453\nUrinary Incontinence\tPlatybasia\t1\t1.6175293416348633\nUrinary Incontinence\tOsteoporosis\t6\t9.705176049809179\nUrinary Incontinence\tOsteoporosis, Postmenopausal\t2\t3.2350586832697266\nUrinary Incontinence\tOsteitis Deformans\t2\t3.2350586832697266\nUrinary Incontinence\tSpinal Diseases\t6\t9.705176049809179\nUrinary Incontinence\tIntervertebral Disk Displacement\t11\t17.792822757983497\nUrinary Incontinence\tSpinal Osteophytosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Stenosis\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis, Psoriatic\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolysis\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolisthesis\t1\t1.6175293416348633\nUrinary Incontinence\tClubfoot\t1\t1.6175293416348633\nUrinary Incontinence\tGranuloma, Giant Cell\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis\t3\t4.852588024904589\nUrinary Incontinence\tArthritis, Rheumatoid\t2\t3.2350586832697266\nUrinary Incontinence\tSjogrens Syndrome                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1
    ## Pasteurellosis, Pneumonic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          0
    ##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Pasteurellosis, Pneumonic
    ## Pleural Neoplasms                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             0.8415571
    ## Muscular Disorders, Atrophic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  0.0000000
    ## Meningomyelocele                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              0.0000000
    ## Sjogrens Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGastroesophageal Reflux\t1\t3.543332367391082\nUrinary Bladder, Overactive\tColitis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIntestinal Pseudo-Obstruction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFecal Incontinence\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLiver Cirrhosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tXerostomia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Apnea Syndromes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCough\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Acute Disseminated\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple Sclerosis\t19\t67.32331498043055\nUrinary Bladder, Overactive\tMyasthenia Gravis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEncephalomyelitis, Autoimmune, Experimental\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAutonomic Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMultiple System Atrophy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCentral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParkinson Disease\t8\t28.346658939128655\nUrinary Bladder, Overactive\tCerebral Palsy\t1\t3.543332367391082\nUrinary Bladder, Overactive\tBrain Ischemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCerebral Infarction\t6\t21.25999420434649\nUrinary Bladder, Overactive\tInfarction, Middle Cerebral Artery\t2\t7.086664734782164\nUrinary Bladder, Overactive\tStroke\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDementia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tAlzheimer Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHydrocephalus, Normal Pressure\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHyperprolactinemia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMovement Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEssential Tremor\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSpinal Cord Diseases\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSpinal Cord Injuries\t26\t92.12664155216812\nUrinary Bladder, Overactive\tMeningomyelocele\t4\t14.173329469564328\nUrinary Bladder, Overactive\tSpinal Dysraphism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAmyloid Neuropathies, Familial\t1\t3.543332367391082\nUrinary Bladder, Overactive\tAtaxia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDelirium\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSyncope\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMemory Disorders\t4\t14.173329469564328\nUrinary Bladder, Overactive\tNeurogenic Inflammation\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMuscle Hypertonia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPain\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPain, Intractable\t1\t3.543332367391082\nUrinary Bladder, Overactive\tParaplegia\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperesthesia\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Neurogenic\t91\t322.44324543258847\nUrinary Bladder, Overactive\tPeripheral Nervous System Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetic Neuropathies\t1\t3.543332367391082\nUrinary Bladder, Overactive\tSleep Disorders, Intrinsic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tRestless Legs Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tGlaucoma\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tProstatic Hyperplasia\t49\t173.623286002163\nUrinary Bladder, Overactive\tProstatitis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tSexual Dysfunction, Physiological\t10\t35.43332367391082\nUrinary Bladder, Overactive\tErectile Dysfunction\t8\t28.346658939128655\nUrinary Bladder, Overactive\tImpotence, Vasculogenic\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrologic Diseases\t21\t74.40997971521271\nUrinary Bladder, Overactive\tUreteral Calculi\t2\t7.086664734782164\nUrinary Bladder, Overactive\tUrethral Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrethral Obstruction\t3\t10.629997102173245\nUrinary Bladder, Overactive\tUrinary Bladder Neck Obstruction\t41\t145.27662706303437\nUrinary Bladder, Overactive\tUrinary Bladder Diseases\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis\t14\t49.60665314347515\nUrinary Bladder, Overactive\tCystitis, Interstitial\t27\t95.66997391955921\nUrinary Bladder, Overactive\tCystocele\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Bladder, Overactive\t1194\t4230.738846664952\nUrinary Bladder, Overactive\tVesico-Ureteral Reflux\t7\t24.803326571737575\nUrinary Bladder, Overactive\tUrination Disorders\t42\t148.81995943042543\nUrinary Bladder, Overactive\tEnuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tNocturnal Enuresis\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHematuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPolyuria\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUrinary Incontinence\t151\t535.0431874760534\nUrinary Bladder, Overactive\tUrinary Incontinence, Stress\t48\t170.07995363477193\nUrinary Bladder, Overactive\tUrinary Incontinence, Urge\t69\t244.48993334998465\nUrinary Bladder, Overactive\tUrinary Retention\t20\t70.86664734782164\nUrinary Bladder, Overactive\tFemale Urogenital Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tFallopian Tube Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tEndometriosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tUterine Prolapse\t4\t14.173329469564328\nUrinary Bladder, Overactive\tPregnancy Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor Complications\t1\t3.543332367391082\nUrinary Bladder, Overactive\tObstetric Labor, Premature\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPuerperal Disorders\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHeart Diseases\t1\t3.543332367391082\nUrinary Bladder, Overactive\tLong QT Syndrome\t1\t3.543332367391082\nUrinary Bladder, Overactive\tTorsades de Pointes\t1\t3.543332367391082\nUrinary Bladder, Overactive\tMyocardial Infarction\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHypertension\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDrug Eruptions\t2\t7.086664734782164\nUrinary Bladder, Overactive\tLichenoid Eruptions\t1\t3.543332367391082\nUrinary Bladder, Overactive\tHyperhidrosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCalcinosis\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus\t1\t3.543332367391082\nUrinary Bladder, Overactive\tDiabetes Mellitus, Experimental\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Mellitus, Type 2\t2\t7.086664734782164\nUrinary Bladder, Overactive\tMetabolic Syndrome X\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHyperlipidemias\t2\t7.086664734782164\nUrinary Bladder, Overactive\tObesity\t3\t10.629997102173245\nUrinary Bladder, Overactive\tDiabetes Complications\t3\t10.629997102173245\nUrinary Bladder, Overactive\tHypogonadism\t2\t7.086664734782164\nUrinary Bladder, Overactive\tHypersensitivity\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCognition Disorders\t8\t28.346658939128655\nUrinary Bladder, Overactive\tSexual Dysfunctions, Psychological\t2\t7.086664734782164\nUrinary Bladder, Overactive\tTranssexualism\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPelvic Organ Prolapse\t7\t24.803326571737575\nUrinary Bladder, Overactive\tGenetic Predisposition to Disease\t1\t3.543332367391082\nUrinary Bladder, Overactive\tCicatrix\t1\t3.543332367391082\nUrinary Bladder, Overactive\tIschemia\t2\t7.086664734782164\nUrinary Bladder, Overactive\tNerve Degeneration\t1\t3.543332367391082\nUrinary Bladder, Overactive\tPostoperative Complications\t6\t21.25999420434649\nUrinary Incontinence\tBacterial Infections\t6\t9.705176049809179\nUrinary Incontinence\tBacteremia\t1\t1.6175293416348633\nUrinary Incontinence\tEpidural Abscess\t2\t3.2350586832697266\nUrinary Incontinence\tNeurosyphilis\t5\t8.087646708174317\nUrinary Incontinence\tFournier Gangrene\t1\t1.6175293416348633\nUrinary Incontinence\tLyme Disease\t2\t3.2350586832697266\nUrinary Incontinence\tMelioidosis\t1\t1.6175293416348633\nUrinary Incontinence\tChlamydia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEnterobacteriaceae Infections\t1\t1.6175293416348633\nUrinary Incontinence\tEscherichia coli Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHelicobacter Infections\t1\t1.6175293416348633\nUrinary Incontinence\tPseudomonas Infections\t2\t3.2350586832697266\nUrinary Incontinence\tBoutonneuse Fever\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculoma\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Miliary\t1\t1.6175293416348633\nUrinary Incontinence\tTuberculosis, Spinal\t2\t3.2350586832697266\nUrinary Incontinence\tTuberculosis, Urogenital\t3\t4.852588024904589\nUrinary Incontinence\tNocardia Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStaphylococcal Infections\t2\t3.2350586832697266\nUrinary Incontinence\tStaphylococcal Skin Infections\t1\t1.6175293416348633\nUrinary Incontinence\tStreptococcal Infections\t1\t1.6175293416348633\nUrinary Incontinence\tInfection\t1\t1.6175293416348633\nUrinary Incontinence\tOsteitis\t2\t3.2350586832697266\nUrinary Incontinence\tOsteomyelitis\t4\t6.470117366539453\nUrinary Incontinence\tSpondylitis\t1\t1.6175293416348633\nUrinary Incontinence\tCommunicable Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tCommunity-Acquired Infections\t1\t1.6175293416348633\nUrinary Incontinence\tCross Infection\t3\t4.852588024904589\nUrinary Incontinence\tAIDS-Related Opportunistic Infections\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Infection\t2\t3.2350586832697266\nUrinary Incontinence\tPelvic Inflammatory Disease\t1\t1.6175293416348633\nUrinary Incontinence\tPregnancy Complications, Infectious\t1\t1.6175293416348633\nUrinary Incontinence\tProsthesis-Related Infections\t5\t8.087646708174317\nUrinary Incontinence\tRespiratory Tract Infections\t2\t3.2350586832697266\nUrinary Incontinence\tSepsis\t1\t1.6175293416348633\nUrinary Incontinence\tSexually Transmitted Diseases\t1\t1.6175293416348633\nUrinary Incontinence\tAbscess\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tLiver Abscess\t1\t1.6175293416348633\nUrinary Incontinence\tUrinary Tract Infections\t118\t190.86846231291386\nUrinary Incontinence\tBacteriuria\t26\t42.05576288250644\nUrinary Incontinence\tPyuria\t2\t3.2350586832697266\nUrinary Incontinence\tWound Infection\t1\t1.6175293416348633\nUrinary Incontinence\tSurgical Wound Infection\t2\t3.2350586832697266\nUrinary Incontinence\tAspergillosis\t1\t1.6175293416348633\nUrinary Incontinence\tCandidiasis\t3\t4.852588024904589\nUrinary Incontinence\tMeningitis, Cryptococcal\t1\t1.6175293416348633\nUrinary Incontinence\tHistoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tWest Nile Fever\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Viral\t1\t1.6175293416348633\nUrinary Incontinence\tEncephalitis, Herpes Simplex\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis\t5\t8.087646708174317\nUrinary Incontinence\tParaparesis, Tropical Spastic\t4\t6.470117366539453\nUrinary Incontinence\tChickenpox\t3\t4.852588024904589\nUrinary Incontinence\tCytomegalovirus Infections\t1\t1.6175293416348633\nUrinary Incontinence\tBurkitt Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Genitalis\t1\t1.6175293416348633\nUrinary Incontinence\tHerpes Zoster\t4\t6.470117366539453\nUrinary Incontinence\tCondylomata Acuminata\t1\t1.6175293416348633\nUrinary Incontinence\tDistemper\t1\t1.6175293416348633\nUrinary Incontinence\tMumps\t1\t1.6175293416348633\nUrinary Incontinence\tCommon Cold\t2\t3.2350586832697266\nUrinary Incontinence\tHTLV-I Infections\t1\t1.6175293416348633\nUrinary Incontinence\tHTLV-II Infections\t2\t3.2350586832697266\nUrinary Incontinence\tHIV Infections\t1\t1.6175293416348633\nUrinary Incontinence\tAcquired Immunodeficiency Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tAIDS Dementia Complex\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroschistosomiasis\t1\t1.6175293416348633\nUrinary Incontinence\tEchinococcosis\t2\t3.2350586832697266\nUrinary Incontinence\tOxyuriasis\t1\t1.6175293416348633\nUrinary Incontinence\tStrongyloidiasis\t1\t1.6175293416348633\nUrinary Incontinence\tSchistosomiasis\t2\t3.2350586832697266\nUrinary Incontinence\tSchistosomiasis mansoni\t2\t3.2350586832697266\nUrinary Incontinence\tToxoplasmosis\t1\t1.6175293416348633\nUrinary Incontinence\tCysts\t11\t17.792822757983497\nUrinary Incontinence\tArachnoid Cysts\t3\t4.852588024904589\nUrinary Incontinence\tBone Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tDermoid Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tEpidermal Cyst\t2\t3.2350586832697266\nUrinary Incontinence\tLymphocele\t1\t1.6175293416348633\nUrinary Incontinence\tOvarian Cysts\t2\t3.2350586832697266\nUrinary Incontinence\tHamartoma\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Lymphoid\t1\t1.6175293416348633\nUrinary Incontinence\tPrecursor Cell Lymphoblastic Leukemia-Lymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tLeukemia, Myeloid, Acute\t3\t4.852588024904589\nUrinary Incontinence\tLeukemia, Monocytic, Acute\t1\t1.6175293416348633\nUrinary Incontinence\tSarcoma, Myeloid\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma\t1\t1.6175293416348633\nUrinary Incontinence\tHodgkin Disease\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Non-Hodgkin\t2\t3.2350586832697266\nUrinary Incontinence\tLymphoma, B-Cell\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, AIDS-Related\t1\t1.6175293416348633\nUrinary Incontinence\tLymphoma, Large B-Cell, Diffuse\t3\t4.852588024904589\nUrinary Incontinence\tLymphoma, Large-Cell, Immunoblastic\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Adenosquamous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinosarcoma\t1\t1.6175293416348633\nUrinary Incontinence\tAngiolipoma\t2\t3.2350586832697266\nUrinary Incontinence\tLipoma\t11\t17.792822757983497\nUrinary Incontinence\tGiant Cell Tumor of Bone\t1\t1.6175293416348633\nUrinary Incontinence\tFibroma\t1\t1.6175293416348633\nUrinary Incontinence\tFibromatosis, Aggressive\t1\t1.6175293416348633\nUrinary Incontinence\tBrenner Tumor\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Muscle Tissue\t1\t1.6175293416348633\nUrinary Incontinence\tLeiomyoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma\t3\t4.852588024904589\nUrinary Incontinence\tRhabdomyosarcoma, Embryonal\t1\t1.6175293416348633\nUrinary Incontinence\tChordoma\t2\t3.2350586832697266\nUrinary Incontinence\tGerminoma\t2\t3.2350586832697266\nUrinary Incontinence\tDysgerminoma\t1\t1.6175293416348633\nUrinary Incontinence\tCraniopharyngioma\t1\t1.6175293416348633\nUrinary Incontinence\tGlioma\t2\t3.2350586832697266\nUrinary Incontinence\tGlioblastoma\t3\t4.852588024904589\nUrinary Incontinence\tEpendymoma\t2\t3.2350586832697266\nUrinary Incontinence\tGanglioglioma\t1\t1.6175293416348633\nUrinary Incontinence\tOligodendroglioma\t2\t3.2350586832697266\nUrinary Incontinence\tNeuroblastoma\t3\t4.852588024904589\nUrinary Incontinence\tNeuroendocrine Tumors\t1\t1.6175293416348633\nUrinary Incontinence\tMelanoma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurilemmoma\t5\t8.087646708174317\nUrinary Incontinence\tParaganglioma\t1\t1.6175293416348633\nUrinary Incontinence\tTeratoma\t2\t3.2350586832697266\nUrinary Incontinence\tChoriocarcinoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Islet Cell\t1\t1.6175293416348633\nUrinary Incontinence\tSyringoma\t1\t1.6175293416348633\nUrinary Incontinence\tAdenoma, Villous\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma\t10\t16.175293416348634\nUrinary Incontinence\tAdenocarcinoma\t32\t51.760938932315625\nUrinary Incontinence\tAdenocarcinoma, Clear Cell\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Follicular\t1\t1.6175293416348633\nUrinary Incontinence\tAdenocarcinoma, Mucinous\t1\t1.6175293416348633\nUrinary Incontinence\tLinitis Plastica\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Ductal, Breast\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Lobular\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Signet Ring Cell\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Intraepithelial Neoplasia\t1\t1.6175293416348633\nUrinary Incontinence\tCarcinoma, Small Cell\t2\t3.2350586832697266\nUrinary Incontinence\tCarcinoma, Squamous Cell\t5\t8.087646708174317\nUrinary Incontinence\tCarcinoma, Transitional Cell\t5\t8.087646708174317\nUrinary Incontinence\tMeningioma\t5\t8.087646708174317\nUrinary Incontinence\tNeurofibroma\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatoses\t1\t1.6175293416348633\nUrinary Incontinence\tNeurofibromatosis 1\t3\t4.852588024904589\nUrinary Incontinence\tMultiple Myeloma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma\t2\t3.2350586832697266\nUrinary Incontinence\tHemangioendothelioma, Epithelioid\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioblastoma\t1\t1.6175293416348633\nUrinary Incontinence\tHemangioma, Cavernous\t1\t1.6175293416348633\nUrinary Incontinence\tAbdominal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tPeritoneal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRetroperitoneal Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tAnal Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBone Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSkull Base Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tBreast Neoplasms\t9\t14.55776407471377\nUrinary Incontinence\tIntestinal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColorectal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tColonic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tRectal Neoplasms\t10\t16.175293416348634\nUrinary Incontinence\tAnus Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tOvarian Neoplasms\t7\t11.322705391444043\nUrinary Incontinence\tPituitary Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tTesticular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tThyroid Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tNasopharyngeal Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tBrain Neoplasms\t13\t21.02788144125322\nUrinary Incontinence\tCerebral Ventricle Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tInfratentorial Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCerebellar Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tHypothalamic Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tCentral Nervous System Cysts\t1\t1.6175293416348633\nUrinary Incontinence\tMeningeal Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tMeningeal Carcinomatosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Cord Neoplasms\t20\t32.35058683269727\nUrinary Incontinence\tEpidural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tMyelitis, Transverse\t5\t8.087646708174317\nUrinary Incontinence\tParaneoplastic Cerebellar Degeneration\t1\t1.6175293416348633\nUrinary Incontinence\tParaneoplastic Polyneuropathy\t1\t1.6175293416348633\nUrinary Incontinence\tPeripheral Nervous System Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPelvic Neoplasms\t6\t9.705176049809179\nUrinary Incontinence\tSweat Gland Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tVascular Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tLung Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tPleural Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrogenital Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Female\t7\t11.322705391444043\nUrinary Incontinence\tFallopian Tube Neoplasms\t2\t3.2350586832697266\nUrinary Incontinence\tUterine Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tEndometrial Neoplasms\t4\t6.470117366539453\nUrinary Incontinence\tUterine Cervical Neoplasms\t17\t27.497998807792676\nUrinary Incontinence\tVaginal Neoplasms\t12\t19.410352099618358\nUrinary Incontinence\tVulvar Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tGenital Neoplasms, Male\t1\t1.6175293416348633\nUrinary Incontinence\tPenile Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tProstatic Neoplasms\t224\t362.32657252620936\nUrinary Incontinence\tUrologic Neoplasms\t3\t4.852588024904589\nUrinary Incontinence\tUreteral Neoplasms\t1\t1.6175293416348633\nUrinary Incontinence\tUrethral Neoplasms\t5\t8.087646708174317\nUrinary Incontinence\tUrinary Bladder Neoplasms\t31\t50.14340959068076\nUrinary Incontinence\tNeoplasms, Multiple Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Second Primary\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasm Invasiveness\t1\t1.6175293416348633\nUrinary Incontinence\tNeoplasms, Unknown Primary\t2\t3.2350586832697266\nUrinary Incontinence\tNeoplasm Recurrence, Local\t10\t16.175293416348634\nUrinary Incontinence\tParaneoplastic Syndromes\t2\t3.2350586832697266\nUrinary Incontinence\tPregnancy Complications, Neoplastic\t1\t1.6175293416348633\nUrinary Incontinence\tBone Diseases, Developmental\t2\t3.2350586832697266\nUrinary Incontinence\tAchondroplasia\t1\t1.6175293416348633\nUrinary Incontinence\tKlippel-Feil Syndrome\t2\t3.2350586832697266\nUrinary Incontinence\tRubinstein-Taybi Syndrome\t1\t1.6175293416348633\nUrinary Incontinence\tMarfan Syndrome\t4\t6.470117366539453\nUrinary Incontinence\tPlatybasia\t1\t1.6175293416348633\nUrinary Incontinence\tOsteoporosis\t6\t9.705176049809179\nUrinary Incontinence\tOsteoporosis, Postmenopausal\t2\t3.2350586832697266\nUrinary Incontinence\tOsteitis Deformans\t2\t3.2350586832697266\nUrinary Incontinence\tSpinal Diseases\t6\t9.705176049809179\nUrinary Incontinence\tIntervertebral Disk Displacement\t11\t17.792822757983497\nUrinary Incontinence\tSpinal Osteophytosis\t1\t1.6175293416348633\nUrinary Incontinence\tSpinal Stenosis\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis, Psoriatic\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolysis\t1\t1.6175293416348633\nUrinary Incontinence\tSpondylolisthesis\t1\t1.6175293416348633\nUrinary Incontinence\tClubfoot\t1\t1.6175293416348633\nUrinary Incontinence\tGranuloma, Giant Cell\t1\t1.6175293416348633\nUrinary Incontinence\tArthritis\t3\t4.852588024904589\nUrinary Incontinence\tArthritis, Rheumatoid\t2\t3.2350586832697266\nUrinary Incontinence\tSjogrens Syndrome                 0.0000000
    ## Pasteurellosis, Pneumonic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     1.0000000

# 4 Function-based methods

## 4.1 BOG

BOG [4] is a method for disease similarity calculating only using disease-gene associations. We designed function BOG to implement this method. And for the purpose of normalizing the matrix produced by method BOG, we implemented function Normalize. For example:

    data(d2g_separation) #get disease-gene associations
    ds<-sample(names(d2g_separation),5)
    ds

    ## [1] "carbohydrate metabolism, inborn errors"
    ## [2] "vascular diseases"
    ## [3] "gastroenteritis"
    ## [4] "psoriasis"
    ## [5] "dyssomnias"

    sim<-BOG(ds,ds,d2g_separation)
    Normalize(sim) #normalize BOG sim scores

    ##                                        carbohydrate metabolism, inborn errors
    ## carbohydrate metabolism, inborn errors                           0.7144599344
    ## vascular diseases                                                0.0009822555
    ## gastroenteritis                                                  0.0000000000
    ## psoriasis                                                        0.0000000000
    ## dyssomnias                                                       0.0000000000
    ##                                        vascular diseases gastroenteritis
    ## carbohydrate metabolism, inborn errors      0.0009822555     0.000000000
    ## vascular diseases                           0.4895724480     0.008820846
    ## gastroenteritis                             0.0088208458     0.574073490
    ## psoriasis                                   0.0165152517     0.015521699
    ## dyssomnias                                  0.0003915147     0.000000000
    ##                                          psoriasis   dyssomnias
    ## carbohydrate metabolism, inborn errors 0.000000000 0.0000000000
    ## vascular diseases                      0.016515252 0.0003915147
    ## gastroenteritis                        0.015521699 0.0000000000
    ## psoriasis                              0.741070889 0.0092075871
    ## dyssomnias                             0.009207587 1.0000000000

Note that disease-gene associations d2g_separation is a list object that can be obtained by function x2y_df2list. Function x2y_df2list take a data.frame which has two columns (one column contains disease ids and one column contains gene ids, each row declares an association between a disease and a gene) as a input. See an example below:

    options(stringsAsFactors = FALSE) #this may be neccessary

    d2g_fundo_sample<-read.table(text = "DOID:5218    IL6
    DOID:8649  EGFR
    DOID:8649   PTGS2
    DOID:8649   VHL
    DOID:8649   ERBB2
    DOID:8649   PDCD1
    DOID:8649   KLRC1
    DOID:5214   MPZ
    DOID:5214   EGR2
    DOID:5210   AMH")

    d2g_fundo_list<-x2y_df2list(d2g_fundo_sample)
    d2g_fundo_list

    ## $`DOID:5218`
    ## [1] "IL6"
    ##
    ## $`DOID:8649`
    ## [1] "EGFR"  "PTGS2" "VHL"   "ERBB2" "PDCD1" "KLRC1"
    ##
    ## $`DOID:5214`
    ## [1] "MPZ"  "EGR2"
    ##
    ## $`DOID:5210`
    ## [1] "AMH"

Function Normalize normalize a matrix or a vector as the following formula: \[NormScore=\frac{OrigScore-MinScore}{MaxScore-MinScore}\]

Here’s an example:

    m<-matrix(1:9,3,3)
    m

    ##      [,1] [,2] [,3]
    ## [1,]    1    4    7
    ## [2,]    2    5    8
    ## [3,]    3    6    9

    Normalize(m)

    ##       [,1]  [,2]  [,3]
    ## [1,] 0.000 0.375 0.750
    ## [2,] 0.125 0.500 0.875
    ## [3,] 0.250 0.625 1.000

## 4.2 PSB

PSB [5] uses not only disease-gene associations but also GO-gene associations. We designed function PSB to implement this method. Function PSB needs disease-GO associations which can be obtained by function HypergeometricTest.

Here’s an example for PSB:

    ## get the data
    data(go2g_sample)
    data(d2go_sample)

    ds<-names(d2go_sample)
    sim<-PSB(ds,ds,d2go_sample,go2g_sample)
    sim

    ##            DOID:5652 DOID:10005  DOID:2290
    ## DOID:5652  4.1743210 0.44099253 0.51055413
    ## DOID:10005 0.4409925 5.82708131 0.09897865
    ## DOID:2290  0.5105541 0.09897865 5.45446576

    Normalize(sim)

    ##             DOID:5652 DOID:10005  DOID:2290
    ## DOID:5652  0.71146461 0.05970806 0.07185197
    ## DOID:10005 0.05970806 1.00000000 0.00000000
    ## DOID:2290  0.07185197 0.00000000 0.93494957

## 4.3 FunSim

FunSim [3] is a method that takes advantage of gene function network data from HumanNet [6]. First we got the raw data from HumanNet, then we normalized the associated log likelihood score of gene pairs. Then we can use function FunSim to mearsure similarity between diseases (note that we use function LLSn2List to convert HumanNet data from data.frame to list, for more efficient calculating):

    ## in this method, we must use disease-gene associations
    ## which genes are represented by entrez ids because of
    ## HumanNet
    data(d2g_fundo_entrezid) ##get disease-gene associations
    data(HumanNet_sample)
    ## we specified 5 DOIDs to match Human_sample
    ds<-c("DOID:8176","DOID:2394","DOID:3744","DOID:8466","DOID:5679")
    llsnlist<-LLSn2List(HumanNet_sample)
    FunSim(ds,ds,d2g_fundo_entrezid,llsnlist)

    ##              DOID:8176  DOID:2394    DOID:3744    DOID:8466 DOID:5679
    ## DOID:8176 1.0000000000 0.43350044 0.4476822789 0.0002666029 0.1457867
    ## DOID:2394 0.4335004444 1.00000000 0.4222353572 0.0166884115 0.1592188
    ## DOID:3744 0.4476822789 0.42223536 1.0000000000 0.0001286379 0.1293250
    ## DOID:8466 0.0002666029 0.01668841 0.0001286379 1.0000000000 0.1349979
    ## DOID:5679 0.1457866621 0.15921884 0.1293250308 0.1349979009 1.0000000

## 4.4 ICod

ICod [7] mearsures disease-disease similarities based on disease-related PPIs. We used an R graph igraph to import PPI data into R. For example:

    ## get disease-gene associations and HPRD PPI data
    data(d2g_fundo_symbol)
    data(PPI_HPRD)

    graph_hprd<-graph.data.frame(PPI_HPRD,directed=FALSE) #get a igraph object based on HPRD PPI data

    ds<-sample(names(d2g_fundo_symbol),5)
    ICod(ds,ds,d2g_fundo_symbol,graph_hprd)

    ##              DOID:3875   DOID:1928   DOID:3744   DOID:3114 DOID:13709
    ## DOID:3875  1.000000000 0.006309080 0.007998635 0.008263260 0.00000000
    ## DOID:1928  0.006309080 1.000000000 0.005191783 0.005433655 0.00000000
    ## DOID:3744  0.007998635 0.005191783 1.000000000 0.007150787 0.00420745
    ## DOID:3114  0.008263260 0.005433655 0.007150787 1.000000000 0.01290766
    ## DOID:13709 0.000000000 0.000000000 0.004207450 0.012907657 1.00000000

## 4.5 Sun’s measures

Sun [8] proposed three measures which use different biological information. These three measures are: annotation-baesd, function-based and topological-based.

### 4.5.1 Sun’s annotation-based measure

Sun’s annotation-based measure used the information of disease-gene association data. We implemented function Sun_annotation to calculate disease-disease similarity:

    data(d2g_separation) ## get disease-gene associations

    ds<-sample(names(d2g_separation),5)
    Sun_annotation(ds,ds,d2g_separation)

    ##                             genetic diseases, inborn spondylarthropathies
    ## genetic diseases, inborn                 1.000000000                 0.00
    ## spondylarthropathies                     0.000000000                 1.00
    ## hypersensitivity, immediate              0.012512031                 0.00
    ## gastroenteritis                          0.005159071                 0.03
    ## death, sudden, cardiac                   0.000990099                 0.00
    ##                             hypersensitivity, immediate gastroenteritis
    ## genetic diseases, inborn                     0.01251203     0.005159071
    ## spondylarthropathies                         0.00000000     0.030000000
    ## hypersensitivity, immediate                  1.00000000     0.030172414
    ## gastroenteritis                              0.03017241     1.000000000
    ## death, sudden, cardiac                       0.00000000     0.000000000
    ##                             death, sudden, cardiac
    ## genetic diseases, inborn               0.000990099
    ## spondylarthropathies                   0.000000000
    ## hypersensitivity, immediate            0.000000000
    ## gastroenteritis                        0.000000000
    ## death, sudden, cardiac                 1.000000000

### 4.5.2 Sun’s function-based measure

Sun’s function-based measure uses both GO term annotations and disease-gene associations to estimate the disease similarity scores. We implemented function Sun_function to perform this method like follows:

    ## get a sample of disease-GO associations
    data(d2go_sample)
    ds<-names(d2go_sample)
    Sun_function(ds,ds,d2go_sample)

    ##             DOID:5652 DOID:10005  DOID:2290
    ## DOID:5652  1.00000000          0 0.02672606
    ## DOID:10005 0.00000000          1 0.00000000
    ## DOID:2290  0.02672606          0 1.00000000

### 4.5.3 Sun’s topology-based measure

Sun’s topology-based measure takes advantage of the topology of PPI network and disease-gene association data to measure disease similarity scores. Futhurmore Function Sun_topology was implemented for this method. And in this method, the graphlet signature of nodes in PPI were calculated by a tool orca [9] (see details in [8]).

Here is an example:

    data(d2g_fundo_symbol)
    data(graphlet_sig_hprd) #get graphlet signatures of genes in HPRD PPI network
    data(weight)
    ds<-sample(names(d2g_fundo_symbol),5)
    Sun_topology(ds,ds,d2g_fundo_symbol,graphlet_sig_hprd,weight)

    ##            DOID:277 DOID:4971  DOID:942 DOID:5214 DOID:3145
    ## DOID:277  1.0000000 0.4176471 0.3647057 0.3269374 0.4341133
    ## DOID:4971 0.4176471 1.0000000 0.4313996 0.4436153 0.4280926
    ## DOID:942  0.3647057 0.4313996 1.0000000 0.3974513 0.3990361
    ## DOID:5214 0.3269374 0.4436153 0.3974513 1.0000000 0.3047308
    ## DOID:3145 0.4341133 0.4280926 0.3990361 0.3047308 1.0000000

## 4.6 Separation

Method Separation is actually a method measuring a netowrk-based separation of disease pairs [10]. But the result can also be turned into similarity scores. And we implemented function Separation2Similarity for this purpose as the following formula: \[SimScore=\frac{MaxSepScore-SepScore}{MaxSepScore-MinSepScore}\]

Here is an example:

    ## get the disease-gene association data and interactome data
    data(d2g_separation)
    data(interactome)

    ## import ppi data to R by igraph
    graph_interactome<-graph.data.frame(interactome,directed=FALSE)

    ## calculate separation of 5 sample diseases
    ds<-sample(names(d2g_separation),5)
    sep<-Separation(ds,ds,d2g_separation,graph_interactome)

    ## convert separation into simialrity
    sim<-Separation2Similarity(sep)
    sim

    ##                               musculoskeletal abnormalities
    ## musculoskeletal abnormalities                    0.71652505
    ## blood platelet disorders                         0.00000000
    ## metabolic syndrome x                             0.09743069
    ## leukemia                                         0.23951908
    ## skin diseases, papulosquamous                    0.14381108
    ##                               blood platelet disorders metabolic syndrome x
    ## musculoskeletal abnormalities              0.000000000          0.097430689
    ## blood platelet disorders                   0.653560906          0.004029854
    ## metabolic syndrome x                       0.004029854          1.000000000
    ## leukemia                                   0.042602463          0.106818682
    ## skin diseases, papulosquamous              0.085946896          0.111487459
    ##                                 leukemia skin diseases, papulosquamous
    ## musculoskeletal abnormalities 0.23951908                     0.1438111
    ## blood platelet disorders      0.04260246                     0.0859469
    ## metabolic syndrome x          0.10681868                     0.1114875
    ## leukemia                      0.73505390                     0.2103534
    ## skin diseases, papulosquamous 0.21035342                     0.8331960

# 5 Visualization

## 5.1 Visualization of disease-gene associations

Disease-gene associations are the most widely used information to measure disease similarity in function-based methods. Here we provide function plot_bipartite for users to observe associations between diseases and genes more intuitively. This function can also visualize other associations like disease-GO term associations. Here’s an example:

    data(d2g_fundo_symbol)
    d2g_sample<-d2g_fundo_symbol[1:10]
    plot_bipartite(d2g_sample)

For two specific diseases, we implemented function plot_topo to visualize the topological relationship of the two diseases’ gene sets in gene network. The following is an example:

    data("PPI_HPRD")
    g<-graph.data.frame(PPI_HPRD,directed = FALSE) #get an igraph graph

    data(d2g_fundo_symbol)
    a<-d2g_fundo_symbol[["DOID:8242"]] # get gene set a
    b<-d2g_fundo_symbol[["DOID:4914"]] # get gene set b

    plot_topo(a,b,g)

## 5.2 Visualization of disease similarity network

We implemented two functions plot_heatmap and plot_net for the disease similarity network’s visualization. Function plot_heatmap is a reuse of function simplot in package DOSE [11] which shows the heatmap of disease similarity network. Given a cutoff, function plot_net will show the relationships among diseases in a graph. For example:

    data(d2g_separation)
    data(interactome)

    graph_interactome<-graph.data.frame(interactome,directed=FALSE)
    ds<-c("myocardial ischemia","myocardial infarction","coronary artery disease",
     "cerebrovascular disorders","arthritis, rheumatoid","diabetes mellitus, type 1",
     "autoimmune diseases of the nervous system","demyelinating autoimmune diseases, cns",
     "respiratory hypersensitivity","asthma","retinitis pigmentosa",
     "retinal degeneration","macular degeneration")

    sep<-Separation(ds,ds,d2g_separation,graph_interactome)
    sim<-Separation2Similarity(sep)
    plot_heatmap(sim,font.size = 3)

    plot_net(sim,cutoff=0.2)

# 6 References

[1] Zhou X Z, Menche J, Barabasi A L, et al. Human symptoms-disease network[J]. Nature communications, 2014, 5.

[2] Van Driel M A, Bruggeman J, Vriend G, et al. A text-mining analysis of the human phenome[J]. European journal of human genetics, 2006, 14(5): 535-542.

[3] Cheng L, Li J, Ju P, et al. SemFunSim: a new method for measuring disease similarity by integrating semantic and gene functional association[J]. PloS one, 2014, 9(6): e99415.

[4] Mathur S, Dinakarpandian D. Automated ontological gene annotation for computing disease similarity[J]. AMIA Summits on Translational Science Proceedings, 2010, 2010: 12.

[5] Mathur S, Dinakarpandian D. Finding disease similarity based on implicit semantic similarity[J]. Journal of biomedical informatics, 2012, 45(2): 363-371.

[6] Lee I, Blom U M, Wang P I, et al. Prioritizing candidate disease genes by network-based boosting of genome-wide association data[J]. Genome research, 2011, 21(7): 1109-1121.

[7] Paik H, Heo HS, Ban H, et al. Unraveling human protein interaction networks underlying co-occurrences of diseases and pathological conditions[J]. Journal of translational medicine, 2014, 12(1): 99.

[8] Sun K, Gonçalves JP, Larminie C. Predicting disease associations via biological network analysis[J]. BMC bioinformatics, 2014, 15(1): 304.

[9] Hočevar T, Demšar J. A combinatorial approach to graphlet counting[J]. Bioinformatics, 2014, 30(4): 559-565.

[10] Menche J, Sharma A, Kitsak M, et al. Uncovering disease-disease relationships through the incomplete interactome[J]. Science, 2015, 347(6224): 1257601.

[11] Yu G, Wang L G, Yan G R, et al. DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis[J]. Bioinformatics, 2015, 31(4): 608-609.