Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector
and covariance matrix per study) rather than individual-level data. Integrates
with the 'nlmixr2'/'rxode2' ecosystem via three estimation methods: a First-Order ('FO')
analytical estimator, a Monte Carlo (MC) estimator, and an Iterative Reweighting
Monte Carlo ('IRMC') estimator. Methods are
based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in
van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.
| Version: |
0.1.0 |
| Depends: |
R (≥ 4.1.0) |
| Imports: |
checkmate, digest, nlmixr2est, nloptr, qs2, randtoolbox, Rcpp, rxode2 |
| LinkingTo: |
Rcpp, RcppEigen |
| Suggests: |
expm, furrr, future, ggplot2, knitr, mnormt, nlmixr2, patchwork, rmarkdown, testthat (≥ 3.0.0) |
| Published: |
2026-06-02 |
| DOI: |
10.32614/CRAN.package.admixr2 (may not be active yet) |
| Author: |
H. van de Beek [aut, cre],
P.A.J. Välitalo [aut],
L.B. Zwep [aut],
J.G.C. van Hasselt [aut] |
| Maintainer: |
H. van de Beek <h.van.de.beek at lacdr.leidenuniv.nl> |
| BugReports: |
https://github.com/LeidenPharmacology/admixr2/issues |
| License: |
GPL (≥ 3) |
| URL: |
https://leidenpharmacology.github.io/admixr2/,
https://github.com/LeidenPharmacology/admixr2 |
| NeedsCompilation: |
yes |
| Citation: |
admixr2 citation info |
| Materials: |
README, NEWS |
| CRAN checks: |
admixr2 results |