The aim of this package is to ease or amplify the process of creating datasets mainly for pharmacometric analyses. The package contains functions to create NONMEM specific variables, perform various time calculations and help in creating dosing records. Finally, multiple functions are present for documentation and QC purposes.
The latest version can be installed using:
devtools::install_github("LeidenAdvancedPKPD/amp.dm")
The article section should get you started. Within this section there is also a PDF that represents a study example, and include code for the main functionality of the package. This example can also be used as a starting point or template for new studies.
This package was initially developed as an in-house package at LAP&P, and was started in 2015. Various versions were developed, where many people within LAP&P helped in making the package better and more robust. Without them this package wouldn’t be possible!
There are many packages for general data management like the entire
tidyverse collection and more specific for pharma the
pharmaverse collection.
This package is more specific for pharmacometric datasets which
require some specific functionality. Related to these type of datasets
there is the NMdata
package. The main difference with this package is that
NMdata combines data management tasks with processing of
NONMEM results. This package is more focused towards dataset creation,
including handling meta data and documentation.
The yspec
and yamlet
packages are mainly build for handling meta data, while this package
handles meta data differently and combines this in the ‘documented’
workflow.